Cytostatin I

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 691, 435 711, 435 712, 435471, 435325, 4352523, 4353201, 536 231, 536 235, 536 243, 536 2431, C07N 14475, C12N 1512, C12N 1563

Patent

active

059773090

ABSTRACT:
A human cytostatin I polypeptide an DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other matastases.

REFERENCES:
Amemiya et al. (1994) J. Antibiotics 47(5):536-540.
Amemiya et al. (1994) J. Antibiotics 47(5):541-544.
Yamazaki et al. (1995) J. Antibiotics 48(10):1138-1140.
Bohmer et al. (1987) Biochem. & Biophys. Res. Comms. 148(3):1425-1431.
Grosse et al. (1991) Methods In Enzymology 198:425-440.
Brandt et al. (1992) Biochem. & Biophys. Res. Comms. 189(1):406-413.
Bansal et al. (1993) Biochem. & Biophys. Res. Comms. 191(1):61-69.
Lehmann et al. (1989) Biomed Biochim Acta 48:143-151.
Behlke et al. (1989) Biochem. & Biophys. Res. Comms. 161(1):363-70.
Brandt et al. (1988) Biochemistry 27:1420-1425.
Bohmer et al. (1984) Exper. Cell Research 150:466-476.
Spener et al. (1990) Mol. & Cell Biochem. 98:57-68.
Yang et al. (1994) J. Cell Biology 127(4):1097-1109.
Grosse et al., "Mammary-Derived Growth Inhibitor (MDGI)," Genes, Oncogenes, and Hormones: Advances in Cellular and Molecular Biology of Breast Cancer (R.B. Dickson & M.E. Lippman (eds.), 1991; pp. 69-96.
Wobus et al. (1990) Virchows Archiv B Cell Pathol. 59:339-342.
Treuner et al. (1994) Gene 147:237-242.
Zavizion et al. (1993) J. Dairy Sci. 76:3721-3726.
Erdmann et al. (1993) Cell Tissue Res. 272:383-389.
Vogel et al. (1992) Progress in Histo-and Cytochemistry 26:159-163.
Binas et al. (1992) In Vitro Cell Dev. Biol. 28A:625-634.
Politis et al. (1992) Domestic Animal Endocrinology 9(1):89-94.
Bohmer et al. (1987) J. Biol. Chem. 262:15137-15143.
Wallukat et al. (1991) Mol. Cell Biochem. 102:49-60.
Erdmann et al. (1991) Acta Histochem. 90:51-54.
Breter et al. (1994) Cell Tissue Res. 277:457-464.
Lowe et al. (1984) J. Biol. Chem. 259(20):12696-12704.
Bohmer (1985) Biochim biophys Acta 846:145-154.
Newcomer et al. (1995) FASEB J. 9:229-239.
Krieg et al. (1993) J. biol. Chem. 268(23):17362-17369.
Yeung, A.K. (1994) FASEB J. 9(4-5):A117.
Tong et al., 74th Ann. Mtg. of the FASEB, Part I, No. A487, (1990).
Ganong. Review of Medical Physiology, 17.sup.th edition, Appleton & Lange, pp. 220, 446, 1995.
Creighton, Proteins. Freeman & Co. pp. 70-73, Structures & Principles, 1984.
Rieger et al. Glossary of Genetics & Cytogenetics, 14.sup.th edition, Sprigner-Verlag pp. 17-19, 1976.
Harlow et al. Antibodies, A Laboratory Manual, Cold Spring Harbor Laboratory Ch 5, p. 76, 1988.
Cunningham et al. Science vol. 244, pp. 1081-1085, 1989.
George et al. Macromolecular Sequencing & Synthesis Ch. 12, pp. 127-149, 1988.
Sherman et al. Proc. Natl. Acad. Sci. USA, vol. 84, pp. 3209-3213, 1987.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cytostatin I does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cytostatin I, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytostatin I will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2136914

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.