Cytostatic platinum organic complexes

Details Cytostatic platinum organic complexes Cytostatic platinum organic complexes

1984-08-03

1987-12-01

Sneed, Helen M. S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

C07F 1500

Patent

active

047105771

ABSTRACT:
1,2-Diaminocyclohexane platinum (II) complexes of the general formula: ##STR1## wherein R.sub.1 and R.sub.2, are selected from nitrate and various organic carboxylate groups, with the proviso that R.sub.1 and R.sub.2 are not both nitrate, and the configuration of the 1,2-diaminocyclohexane being selected from cis, trans-d and trans-1, have been found to exhibit potent cytostatic activity.
They may be made by reacting a starting material, in which R.sub.1 and R.sub.2 are nitrate, with the appropriate carboxylic acid or salt thereof.

REFERENCES:
patent: 4115418 (1978-09-01), Gale et al.
patent: 4137248 (1979-01-01), Gale et al.
patent: 4140707 (1979-02-01), Cleare et al.
patent: 4169846 (1979-10-01), Kidani et al.
patent: 4200583 (1980-04-01), Kidani et al.
patent: 4255347 (1981-03-01), Kidani et al.
patent: 4256652 (1981-03-01), Kidani et al.
patent: 4477387 (1984-10-01), Kidani et al.
Speer et al, J. Clinical Hematology and Oncology, vol. 7, (3), p. 856 (1977).
Hackh's Chemical Dictionary, 3rd Edition, McGraw Hill Book Co., Inc. N.Y., pp. 509 and 832 (1944).
Ridgway et al, J. Clin Hematol. Oncol. 7(1) pp. 220-230 (1977).
Chemical Abstracts 84 54030n (1976).
Chemical Abstracts 88 570c(1978).

Affiliated with

Also associated with

Rating

Cytostatic platinum organic complexes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cytostatic platinum organic complexes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytostatic platinum organic complexes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1932334