Cytostatic or cytotoxic combination of active substances for use

Details Cytostatic or cytotoxic combination of active substances for use Cytostatic or cytotoxic combination of active substances for use

1994-09-22

1996-11-26

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530324, A61K 3800, A01N 3718, C07K 500, C07K 700

Patent

active

055785719

ABSTRACT:
According to this invention the combination of active substances for use in therapeutic procedures consists of at least one cytostatic compound, e.g. vincristine, methotrexate, cisplatin as the first agent and at least one histone and/or one active histone fragment with cytostatic or cytotoxic activity as the second agent. Both active agents act synergistically at the site of the pathogenic process.

REFERENCES:
patent: 4902505 (1990-02-01), Pardridge et al.
Buxman, J. Invest. Derm., vol. 73, No. 3, pp. 250-255, 1979.
Ginsburg et al., Biological Abstracts, vol. 78, 8, 1984, Abst No. :59767.

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