Cytostatic lanthanum compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Rare earth containing

Reexamination Certificate

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C424S001110, C424S001650, C424S009100, C514S188000

Reexamination Certificate

active

07122643

ABSTRACT:
Lanthanum compounds are provided having general formulas (I) Rni+Yin−and (II) Rb+Yb−which may be used as medicaments in the prophylaxis and/or treatment of cancer diseases. In formula (I), R is a group of general formula (A):and in general formula (II) Rbis a group of general formula (B):

REFERENCES:
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Charpentier, L.J., et al., “Observations on the Rare Earths—LXXXIV—The Preparation and Properties of 1,2-Propanediamine Complexes”,J. inorg. nucl. Chem.,vol. 32, pp. 3575-3584.
Roesky, P.W., et al. “Aminotroponimines as Ligands for Yttrium and Lanthanide Complexes”,Institut für Anorganische Chemic, vol. 130, No. 7, pp. 859-862 (1997).
Golub, A.M., et al., “Synthesis and Properties of bipyridne and phenanthroline complexes of selenocyanates of the lanthanides”,Zh. Obsch. Khim,vol. 39, No. 6, pp. 1382-1387 (1969), Abstract Only.
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Eremin, Y.G., et al., “On three-component complexes of yttrium and rare earth elements with 2,2′-bipyridine and o-phenanthroline”,Zh. Obsch. Khim.,vol. 21, No. 2, pp. 387-394—(1976), Abstract Only.
Mohan, M., et al., “Synthesis and magnetic and spectral properties of some lanthanide(III) chelates of pyridine-2-aldoxime”,Gazzetta Chimica Italiana,Vo. 110, pp. 293-299 (1980).
Komiyama, M., et al., “Molecular Design of Artificial Enzymes which Selectively Hydrolyze Nucleic Acids—Novel Tools for Future Biotechnology and Cancer Therapy”,Journal of the Faculty of Engineering, Univ. of Tokyo,vol. 42, No. 2, pp. 143-154 (1993).
Russell J. Foster et al., “Complexes of 1,8-naphthyridines. X Complexes of 1,8-naphthyridine with rare earth nitrates”,Chemical Abstracts,vol. 77, No. 26, Abstract 172097t (1972).
Linda J. Charpentier et al., “Rare Earths. LXXXIV. Preparation and properties of 1,2-propanediamine complexes”,Chemical Abstracts,vol. 74, No. 6, Abstract 27594m (1971).
Peter W. Roesky, “Aminotroponimines as Ligands for Yttrium and Lanthanide Complexes”,Chem. Ber./Recueil,vol. 130, pp. 859-862, (1997).

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