Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-12-04
2007-12-04
Russel, Jeffrey Edwin (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S283000, C514S401000, C514S539000, C514S562000, C530S330000, C530S331000, C530S345000
Reexamination Certificate
active
10096120
ABSTRACT:
The present invention relates to cytostatics which have a tumor-specific action as a result of linkage to αvβ3integrin antagonists via preferred linking units which can be selectively cleaved by elastase, i.e. by an enzyme which can especially be found in tumor tissue. The preferred linking units provide sufficient stability of the conjugate of cytostatic and αvβ3integrin antagonist in biological fluids and, at the same time, the desired intracellular action within tumor cells as a result of its specific enzymatic or hydrolytic cleavability with release of the cytostatic.
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Albers Markus
Baumgarten Jörg
Lerchen Hans-Georg
Schoop Andreas
Bayer Akiengesellschaft
Russel Jeffrey Edwin
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