Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-12-17
2011-12-06
Chandrakumar, Nizal (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C548S361100
Reexamination Certificate
active
08071779
ABSTRACT:
The present invention is directed to synthetic cytoskeletal active compounds that are inhibitors of rho-associated protein kinase. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with cytoskeletal reorganization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or Formula II, wherein said amount is effective to influence the actomyosin interactions, for example by leading to cellular relaxation and alterations in cell-substratum adhesions.
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Supplementary European Search Report, Jul. 14, 2011.
Crean Christopher S.
DeCamp Jonathan Bryan
Lampe John W.
Pelz Nicholas F.
Peterson Ward M.
Chandrakumar Nizal
Inspire Pharmaceuticals Inc.
Kung Viola T.
Perkins Coie LLP
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