Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-09-04
1998-10-20
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514885, 536123, 5361231, 536124, 536127, 536128, A61K 31715, C08B 3700, C07G 300
Patent
active
058246592
ABSTRACT:
The present invention relates to a glucose-rich, mannose-containing oligosaccharide described herein has a molecular weight of approximately 1,000-5,000 daltons and is separated from interfering aloe components. The oligosaccharide inhibits loss of skin immunocompetency which is induced by ultraviolet irradiation. The oligosaccharide is obtained by cellulase cleavage of a precursor block polysaccharide of Aloe (FIG. 1) and has about 75% glucose, about 25% mannose and trace galactose. The precursor polysaccharide has a molecular weight of >2,000,000 daltons, is about 73% hexose with a total hexose to reducing sugar ratio of about 23:1. This polysaccharide is about 7% glucose, about 85% mannose and about 4% galactose. Also described is a method for obtaining an immunoprotective oligosaccharide by treating an Aloe extract with cellulase at a concentration of less than about 2 grams per 215 liters.
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Kripke Margaret L.
Pelley Ronald P.
Strickland Faith M.
Board of Regents , The University of Texas System
Kight John
Lee Howard C.
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