Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1997-03-18
2000-02-01
Carr, Deborah D
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544170, 544171, 544175, 554 61, 554 63, 554103, 554108, 554109, 554110, 562512, 562553, 562567, C07D26532
Patent
active
060204893
ABSTRACT:
Water or lipid soluble, pharmacologically active, antioxidant, anti-phospholipase compounds that are chemically defined. The compounds protect mammalian cells by inhibiting PLA.sub.2 and preventing oxidation. In particular, each compound has at least two fatty moieties and no active hydroxy group. The compound may also have at least one ionizable group, which may be a carboxyl group, and each of the fatty moieties has from sixteen to twenty carbon atoms and at least one cis-unsaturated double bond.
REFERENCES:
patent: 4701469 (1987-10-01), Mendy et al.
patent: 4927658 (1990-05-01), Klemann et al.
Brem, et al., "Interstitial Chemotherapy with Drug Polymer Implants for the Treatment of Recurrent Gliomas", J. Neurosurg, vol. 74, pp. 441-446 (1991).
Clay, et al., "Structural Characterization of Lipids Which Develop During Blood Storage and Prime Neutrophils Via Platelet Activating Factor Receptors", Third International Congress: Eicosanoids & Other Bioactive Lipids in Cancer, Inflammation & Radiation Repair, Abstract #192.
Clapp, et al., "Phospholipase A.sub.2 -induced Neurotoxicity in vitro and in vivo in rats", Brain Research, vol. 693, pp. 101-111 (1995).
Franson et al., "Mechanism(s) of Cytoprotective and Anti-Inflammatory Activity of PGB.sub.1 Oligomers: PGB.sub.x has Potent Anti-Phospholipase A.sub.2, and Anti-Oxidant Activity", Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 43, pp. 63-70 (1991).
O'Brien, David F.; Lingbiel, Richard T.; Specht, Donald P.; Tyminski, Patricia N., "Preparation and characterization of polymerized liposomes", Ann. N.Y. Acad. Sci., No. 446, pp. 282-95 (1985).
Stephenson, et al., "Cytosolic Phospholipase A.sub.2 (.sub.c PLA.sub.2) Immunoreactivity is Elevated in Alzheimer's Disease Brain," Neurobiology of Disease, vol. 3, pp. 51-63 (1996).
Yonese, et al., "Detection for Heating Products of Ricinoleic Acid and Separation of Polyricinoleic Acids", Chemical Abstracts, vol. 95, No. 14, Abstract No. 117410, p. 105 (1981) (Abstract Only).
Vitsina, et al., "Cooling Liquid Lubricant for Cold Processing of Metals", Chemical Abstracts, vol. 068, No. 12, Abstract No. 052458, p. 5097 (1968) (Abstract Only).
Bhatnagar, et al., "Synthetic Ester Lubricants: Pt. I-Synthesis and Properties of 2,2-Dialkyl-l, 3-Propanediol Esters", J. Indian Chem. Soc., vol. LVIII, pp. 594-596 (1981).
Watanabe, et al., "New Additives Derived from Fatty Acids for Water-Based Cutting Fluids", Journal of the American Oil Chemists' Society, vol. 62, No. 1 pp. 125-127 (1985).
Teupel, et al., "Analysis of ricinoleic acid monoglycerides by column chromatography and nuclear magnetic resonance spectroscopy", Tenside--vol. 5 (9-10) pp. 275-278 (1968).
"Enzymatic Preparation of Ricinoleic Acid Esters of Long-Chain Monohydric Alcohols and Properties of the Esters", S. Ghoshray and D.K. Bhattacharya; JAOCS, vol. 69, No. 1 (Jan. 1992).
Franson Richard C.
Ottenbrite Raphael M.
Carr Deborah D
Virginia Commonwealth University
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