Organic compounds -- part of the class 532-570 series – Organic compounds – Fatty compounds having an acid moiety which contains the...
Patent
1996-04-15
1999-01-12
Reamer, James H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Fatty compounds having an acid moiety which contains the...
554 78, 554 96, 554103, 554224, 514552, C07C 6958
Patent
active
058592717
ABSTRACT:
The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.
REFERENCES:
patent: 4701469 (1987-10-01), Mendy et al.
patent: 4927658 (1990-05-01), Klemann et al.
Ghoshray, S. et al., "Enzymatic Preparation of Ricinoleic Acid Esters of Long-Chain Monohydric Alcohols and Properties of the Esters", JAOCS, vol. 69, No. 1, pp. 85-88 (1992).
Yonese, et al., "Detection for Heating Products of Ricinoleic Acid and Separation of Polyricinoleic Acids", Chemical Abstracts, vol. 95, No. 14, Abstract No. 117410, p. 105 (1981) (Abstract Only).
Vitsina, et al., "Cooling Liquid Lubricant for Cold Processing of Metals", Chemical Abstracts, vol. 068, No. 12, Abstract No. 052458, p. 5097 (1968) (Abstract Only).
Bhatnagar, et al. "Synthetic Ester Lubricants: Pt. I-Synthesis and Properties of 2,2-Dialkyl-1, 3-Propanediol Esters", J. Indian Chem. Soc., vol. LVIII, pp. 594-596 (1981).
Watanabe, et al. "New Additives Derived from Fatty Acids for Water-Based Cutting Fluids", Journal of the American Oil Chemists' Society, vol. 62, No. 1, pp. 125-127 (1985).
Teupel, et al., "Analysis of ricinoleic acid monoglycerides by column chromatography and nuclear magnetic resonance spectroscopy", Tenside, vol. 5 (9-10), pp. 275-278 (1968).
O'Brien, David F.; Lingbiel, Richard T.; Specht, Donald P.; Tyminski, Patricia N. "Preparation and characterization of polymerized liposomes", Ann. N.Y. Acad. Sci., vol. 446, pp. 282-295, (1985).
Stephenson, et al., Cytosolic Phospholipase A.sub.2 (.sub.c PLA.sub.2) Immunoreactivity is Elevated in Alzheimer's Disease Brain,, Neurobiology of Disease, vol. 3, pp. 51-63, (1996).
Clapp et al., Phospholipase A.sub.2 - induced neurotoxicity in vitro and in vivo in rats, Brain Research, vol. 693, pp. 101-111 (1995).
Clay et al., Structural Characterization of Lipids Which Develop During Blood Storage and Prime Neutrophils Via Platelet Activating Factor Receptors, Third International Congress: Eicosanoids & Other Bioactive Lipids in Cancer, Inflammation & Radiation Repair, Abstract #192, (1993).
Brem et al., Interstitial Chemotherapy with Drug Polymer Implants for the Treatment of Recurrent Gliomas, J. Neurosurg., vol. 74, pp. 441-446 (1991).
Franson et al., Mechanism(s) of Cytoprotective and Anti-Inflammatory Activity of PGB.sub.1 Oligomers: PGB.sub.x has Potent Anti-Phospholipase A.sub.2, and Anti-Oxidant Activity, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 43, pp. 63-70 (1991).
Franson Richard C.
Ottenbrite Raphael M.
Reamer James H.
Virginia Commonwealth University
LandOfFree
Cytoprotective compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cytoprotective compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytoprotective compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1518114