Cytoprotective, biocompatible, retrievable macrocapsule containm

Details Cytoprotective, biocompatible, retrievable macrocapsule containm Cytoprotective, biocompatible, retrievable macrocapsule containm

1996-05-23

1998-06-02

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

420486, 420489, 420490, 420491, 424499, 435174, 435177, 435180, 435182, 514866, A61K 948, A61K 950, C12N 1100

Patent

active

057595780

ABSTRACT:
The present invention is directed to a macrocapsule for encapsulating microcapsules containing biologically active material, such as living cells or free living cells, to make the system more biocompatible by decreasing the surface area and surface roughness of microencapsulated biological materials; increasing mechanical stability of microencapsulated biological materials; enhancing cytoprotectivity by increasing diffusion distance of encapsulated biological material from cytotoxins secreted in vivo; providing retrievability of microencapsulated material; and providing a system of sustained release of the cellular products. The method for producing such a macrocapsule containing the microcapsules is also disclosed.

REFERENCES:
patent: 4352883 (1982-10-01), Lim
patent: 4663286 (1987-05-01), Tsang et al.
patent: 4833081 (1989-05-01), Walker
patent: 5084350 (1992-01-01), Chang et al.
patent: 5545423 (1996-08-01), Soon-Shiong

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