Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-04-15
1999-09-28
Feisee, Lila
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 72, 435325, 435 691, 530350, 530300, 536 235, 536 231, G01N 33566, G01N 3353, C12N 1512, C12N 510
Patent
active
059587059
ABSTRACT:
The present invention provides purified and isolated polynucleotides encoding IRP (integrin regulatory protein) polypeptides which regulate .beta..sub.2 and .beta..sub.7 integrins and which are contemplated to participate in integrin signaling and/or recycling pathways. Also provided are methods for identifying modulators of IRP activities and methods for identifying other proteins which interact with IRP polypeptides in signaling pathways. Modulators of IRP interactions are contemplated to be useful, for example, in monitoring and treating inflammatory processes involving leukocytes.
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Schreiner, et al. "Leu
Lispky Brian P.
Staunton Donald E.
Feisee Lila
ICOS Corporation
Kaufman Claire M.
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