Cytoplasmic Modulators of Integrin Binding/Signalling

Details Cytoplasmic Modulators of Integrin Binding/Signalling Cytoplasmic Modulators of Integrin Binding/Signalling

1996-01-05

1999-07-13

Chan, Christina

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 435325, 536 235, 530353, C12P 2106

Patent

active

059225700

ABSTRACT:
The present invention relates to purified and isolated polynucleotides encoding a polypeptide which specifically bind to a cytoplasmic portion of an integrin. Specifically, the invention provides a FLP-1-encoding polynucleotide and the polypeptide product of the gene. Expression vectors comprising the polynucleotide, antibodies which recognize the polypeptide, hybridomas which secrete the antibodies, and method to identify modulators of interaction of the polypeptide with .beta..sub.7 subunits sequences are also provided.

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