Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Scleroproteins – e.g. – fibroin – elastin – silk – etc.
Patent
1997-01-06
1999-09-07
Chan, Christina Y.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Scleroproteins, e.g., fibroin, elastin, silk, etc.
530350, 536 235, A61K 3817
Patent
active
059488913
ABSTRACT:
The present invention relates to purified and isolated polynucleotides encoding a polypeptide which specifically bind to a cytoplasmic portion of an integrin. Specifically, the invention provides a FLP-1-encoding polynucleotide and the polypeptide product of the gene. Expression vectors comprising the polynucleotide, antibodies which recognize the polypeptide, hybridomas which secrete the antibodies, and method to identify modulators of interaction of the polypeptide with .beta..sub.7 subunits sequences are also provided.
REFERENCES:
patent: 5506126 (1996-04-01), Seed et al.
Altin et al., "A One-Step Procedure for Biotinylation and Chemical Cross-Linking of Lymphocyte Surface and Intracellular Membrane-Associated Molecules," Anal. Biochem. 224:382-389 (1995).
Arnaout, Amin M., "Structure and Function of the Leukocyte Adhesion Molecules CD11/CD18," Blood 75(5):1037-1050 (1990).
Baron et al. "The Pathogenesis of Adoptive Murine Autoimmune Diabetes Requires an Interaction between .alpha.4-Integrins and Vascular Cell Adhesion Molecule-1," J. Clin. Invest. 93:1700-1708 (1994).
Baron et al. "Surface Expression of .alpha.4 Integrin by CD4 T Cells Is Required for Their Entry into Brain Parenchyma," J. Exp. Med. 177:57-68 (1993).
Burkly et al., "Protection Against Adoptive Transfer of Autoimmune Diabetes Mediated Through Very Late Antigen-4 Integrin," Diabetes 43:529-534 (1994).
Clark and Brugge, "Integrins and Signal Transduction Pathways" The Road Taken, Science 268:233-239 (1995).
Cunningham et al., "Actin-Binding Protein Requirement for Cortical Stability and Efficient Locomotion," Science 255:325-327 (1992).
Durfee et al., "The Retinoblastoma Protein Associates with the Protein Phosphatase Type 1 Catalytic Subunit," Genes & Developement 7:555-569 ((1993).
Ezzell et al., "Localization of the Domain of Actin-binding Protein That Binds to Membrane Glycoprotein Ib and Actin in Human Platelets," J. Biol. Chem. 263(26):13302-13309 (1988).
Ferguson et al., "Antigen-Independent Processes in Antigen-Specific Immunity," J. Immunol. 150(4):1172-1182 (1993).
Gorlin et al., "Human Endothelial Actin-binding Protein (ABP-280, Nonmuscle Filamin): A Molecular Leaf Spring," J. Cell Biol. 111:1089-1105 (1990).
Gumbiner et al., "Proteins Associated with the Cytoplasmic Surface of Adhesion Molecules," Neuron 11:551-564 (1993).
Hemler et al., "Structure of the Integrin VLA-4 and its Cell-Cell and Cell-Matrix Adhesion Functions," Immunol Rev. 114:45-60 (1990).
Jutila, Mark A., "Function and Regulation of Leukocyte Homing Receptors," J. Leukocyte Biol. 55:133-140 (1994).
Kilshaw et al. "A New Surface Antigen on Intraepithelial Lymphocytes in the Intestine," Eur. J. Immunol. 20:2201-2207 (1990).
Kishimoto et al., "Cloning of the .beta. Subunit of the Leukocyte Adhesion Proteins: Homology to an Extracellular Matrix Receptor Defines a Novel Supergene Family," Cell 48:681-690 (1987).
LaFlamme et al., "Regulation of Fibronectin Receptor Distribution," J. Cell Biol. 117(2):437-447 (1992).
Lazarovits et al., "Differential Expression in Rheumatoid Synovium and Synovial Fluid of .alpha.4.beta.7 Integrin," J. Immunol. 151(11):6482-6489 (1993).
Leedman et al., "Cloning from the Thyroid of a Protein Related to Actin Binding Protein that is Recognized by Graves Disease Immunoglobulins," Proc. Natl. Acad. Sci. 90:5994-5998 (1993).
Lobb and Hemler, "The Pathophysiologic Role of .alpha.4 Integrins In Vivo," J. Clin. Invest. 94:1722-1728 (1994).
McEver, Rodger P., "Leukocyte-Endothelial Cell Interactions," Curr. Opin. Cell. Biol. 4:840-849 (1992).
Milne and Piper, "The Role of the VLA-4 Integrin in a Model of Airway Inflammation in the Guinea-Pig," Br. J. Pharmacol 112:82P (Abstr) (1994).
Miyamoto et al., "Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function," Science 267:883-835 (1995).
Mulligan et al., "Role of .alpha..sub.1, .beta..sub.2 Integrins and ICAM-1 in Lung Injury after Deposition of IgG and IgA Immune Complexes," J. Immunol. 150(6):2407-2417 (1993a).
Mulligan et al., "Requirements for Leukocyte Adhesion Molecules in Nephrotoxic Nephritis," J. Clin. Invest. 91:577-587 (1993b).
Nakajima et al., "Role of Vascular Cell Adhesion Molecule 1/Very Late Activation Antigen 4 and Intercellular Adhesion Molecule 1/Lymphocyte Function-associated Antigen 1 Interactions in Antigen-induced Eosinophil and T Cell Recruitment into the Tissue," J. Exp. Med. 179:1145-1154 (1994).
Paul et al., "The Efficacy of LFA-1 and VLA-4 Antibody Treatment in Rat Vascularized Cardiac Allograft Rejection," Transplantation, 55(5):1196-1199 (1993).
Pavalko and Otey, "Role of Adhesion Molecule Cytoplasmic Domains in Mediating Interactions with the Cytoskeleton," Proc. Soc. Exp. Biol. Med., 205:282-293, 1994.
Podolsky et al., "Attenuation of Colitis in the Cotton-top Tamarin by Anti-.alpha.4 integrin Monoclonal Antibody," J. Clin. Invest. 92:372-380 (1993).
Pretolani et al., "Antibody to Very Late Activation Antigen 4 Prevents Antigen-induced Bronchial Hyperactivity and Cellular Infiltration in the Guinea Pig Airways," J. Exp. Med. 180:795-805 (1994).
Schweighoffer et al., "Selective Expression of Integrin .alpha.4.beta.7 on a Subset of Human CD4.sup.+ Memory T Cells with hallmarks of Gut-Trophism," J. Immunol. 151(2):717-729 (1993).
Sharma et al., "Direct Interaction of Filamin (ABP-280) with the .beta.2-Integrin Subunit CD18," J. Immunol. 154:3461-3470 (1995).
Springer et al., "Traffic Signals for Lymphocyte Recirculation and Leukocyte Emigration: The Multistep Paradigm," Cell 76:301-314 (1994).
Van der Vireen et al., "A Novel Leukointegrin, .alpha.d.beta.2, Binds Preferentially to ICAM-3," Immunity 3:683-690 (1995).
Weg et al., "A Monoclonal Antibody Recognizing Very Late Activation Antigen-4 Inhibits Eosinophil Accumulation In Vivo," J. Exp. Med. 177:561-566 (1993).
Winn and Harlan, "CD18-Independent Neutrophil and Mononuclear Leukocyte Emigration into the Peritoneum of Rabbits," J. Clin. Invest. 92:1168-1173 (1993).
Yang et al., "Inhibition of Insulitis and Prevention of Diabetes in Nonobese Diabetic Mice by Blocking L-selectin and Very Late Antigen 4 Adhesion Receptors," Proc. Natl. Acad. Sci. USA 90:10494-10498 (1993).
Yednock et al., "Precention of Experimental Autoimmune Encephalomyelitis by Antibodies Against .alpha.4.beta.1 Integrin," Nature 356:63-66 (1992).
Salot Harris Edith A.
Staunton Donald E.
Chan Christina Y.
ICOS Corporation
Nolan Patrick J.
LandOfFree
Cytoplasmic modulators of integrin binding does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cytoplasmic modulators of integrin binding, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytoplasmic modulators of integrin binding will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1805393