Cytoplasmic antiproteinase-2 and coding sequences

Details Cytoplasmic antiproteinase-2 and coding sequences Cytoplasmic antiproteinase-2 and coding sequences

1995-02-08

1998-01-27

Grimes, Eric

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 43525411, 4353201, 435325, 530413, 536 235, C12N 510, C12N 1515, C12N 1563, C12N 2102

Patent

active

057121176

ABSTRACT:
Cytoplasmic Antiproteinase-2 and Cytoplasmic Antiproteinase-3 nucleic acids and serine protease inhibitor proteins encoded thereby are useful in the purification of proteins and in the treatment of inflammatory diseases and diseases involving apoptosis.

REFERENCES:
patent: 5578705 (1996-11-01), Sprecher
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Gagliardini et al., "Prevention of Vertebrate Neuronal Death by the crmA Gene," Science 263: 826-828 (Feb., 1994).
Potempa et al., "The Serpin Superfamily of Proteinase Inhibitors: Structure, Function, and Regulation" J. Biol. Chem. 269: 15957-15960 (Jun., 1994).
Wang et al., "Ich-1, an Ice/ced-3-Related Gene, Encodes Both Positive and Negative Regulators of Programmed Cell Death," Cell 78: 739-750 (Sep., 1994).
Morgenstern et al., "Complementary DNA Cloning and Kinetic Characterization of a Novel Intracellular Serine Proteinase Inhibitor: Mechanism of Action with Trypsin and Factor Xa as Model Proteinases," Biochem. 33:3432-3441 (1994).
Patston et al., "A Database of Recombinant Wild-type and Mutant Serpins" Thromb. Haemostas. 72:166-179 (1994).

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