Cytophaga-derived immunopotentiator

Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Treating animal or plant material or micro-organism

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435267, 435270, 424 88, 514 54, 536 11, C08B 0000, C08B 3700, A61K 31715, A61K 3900

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049786229

ABSTRACT:
Substantially pigment-free gliding bacteria adjuvant (GBA) is isolated from medium in which Cytophaga strain GB-2 has been cultured by extraction with acetone to remove pigment, enzymatic digestion and filtration to remove residual protein and nucleic acids, and affinity chromatography to remove residual lipopolysaccharide. This pure form of GBA shows unexpectedly high specific immunopotentiating activity relative to crude GBA.

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