Cytopathic viruses for therapy and prophylaxis of neoplasia

Details Cytopathic viruses for therapy and prophylaxis of neoplasia Cytopathic viruses for therapy and prophylaxis of neoplasia

1996-04-29

1997-10-14

Degen, Nancy

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4352351, 435375, 536 231, 536 241, C12N 510, C12N 701, C07H 2104

Patent

active

056771789

ABSTRACT:
Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 and/or RB function. The mutant virus is able to substantially produce a replication phenotype in neoplastic cells but is substantially unable to produce a replication phenotype in non-replicating, non-neoplastic cells having essentially normal p53 and/or RB function. The preferential generation of replication phenotype in neoplastic cells results in a preferential killing of the neoplastic cells, either directly or by expression of a cytotoxic gene in cells expressing a viral replication phenotype.

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