Cytopathic viruses for therapy and prophylaxis of neoplasia

Details Cytopathic viruses for therapy and prophylaxis of neoplasia Cytopathic viruses for therapy and prophylaxis of neoplasia

1998-07-07

1999-10-26

Degen, Nancy

Chemistry: molecular biology and microbiology

Process of mutation, cell fusion, or genetic modification

424 932, 424 933, 424 936, 4352351, 435236, 4353201, 514 44, C12N 1501, C12N 704, C12N 1586, A61K 3170

Patent

active

059727063

ABSTRACT:
Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 and/or RB function. The mutant virus is able to substantially produce a replication phenotype in neoplastic cells but is substantially unable to produce a replication phenotype in non-replicating, non-neoplastic cells having essentially normal p53 and/or RB function. The preferential generation of replication phenotype in neoplastic cells results in a preferential killing of the neoplastic cells, either directly or by expression of a cytotoxic gene in cells expressing a viral replication phenotype.

REFERENCES:
patent: 5801029 (1998-09-01), McCormick
patent: 5856181 (1999-01-01), McCormick

Affiliated with

Also associated with

Rating

Cytopathic viruses for therapy and prophylaxis of neoplasia does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cytopathic viruses for therapy and prophylaxis of neoplasia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytopathic viruses for therapy and prophylaxis of neoplasia will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-762945