Cytomodulating peptide for inhibiting lymphocyte activity

Details Cytomodulating peptide for inhibiting lymphocyte activity Cytomodulating peptide for inhibiting lymphocyte activity

1995-05-03

2000-12-19

Gambel, Phillip

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

4241841, 514 2, 514 13, 514885, 530300, 530326, 530350, 530403, 530868, 530329, A61K 3804, A61K 3808, A61K 3817, C07K 700

Patent

active

061624349

ABSTRACT:
Novel oligopeptides comprising a sequence associated with HLA-B .alpha..sub.1 domain, but comprising a tyrosine-tyrosine-tryptophan triad are provided for use in inhibiting cytotoxic activity of CTLs and natural killer cells. By combining the subject compositions with mixtures of cells comprising the cytotoxic cells and cells which would otherwise activate the cytotoxic cells, lysis of the target cells can be substantially inhibited. The oligopeptides may be joined to a wide variety of other groups or compounds for varying the activity of the subject compositions. The subject compositions may be administered by any convenient means to a host to inhibit CTL and NK attack on tissue, particularly involved with xenogeneic or allogeneic transplants.

REFERENCES:
Buelow et al., Immunomodulation by Soluble HLA Class I (1995) Transplantation, vol. 59, No. 5:649-654.
Wood, W. B. et al. (Eds.) Biochemistry Benjamin/Cummings Publishing Co., Menlo Park, CA, pp. 14-15, 1981.
Bjorkman, P. J. et al. Nature 329: 506-512 (1987) Mar. 21, 2000.
Dal Porto, J. et al. Proc. Natl. Acad. Sci. USA 90: 6671-6675 (1993).

Affiliated with

Also associated with

Rating

Cytomodulating peptide for inhibiting lymphocyte activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cytomodulating peptide for inhibiting lymphocyte activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytomodulating peptide for inhibiting lymphocyte activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-268948