Cytomegalovirus proteinase

Details Cytomegalovirus proteinase Cytomegalovirus proteinase

1991-11-27

1995-07-18

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4352351, 530826, A61K 39245, C07K 14045, C12N 950, C12N 701

Patent

active

054340748

ABSTRACT:
A herpes virus proteinase has been found to be encoded by a member of a family of four nested genes in simian cytomegalovirus. Another member of the nested genes encodes the assembly protein precursor, which is a substrate for the proteinase. Homologous genes are found in other herpes viruses. Cleavage sites recognized by the proteinase are identified in cytomegalovirus and are found to be highly conserved in other herpes viruses. Substrates, inhibitors, assay kits, and methods of assaying are provided which rely on the proteinase and its activity.

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