Cytomegalovirus gene function and methods for developing...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Reexamination Certificate

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Reexamination Certificate

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07407744

ABSTRACT:
A global functional analysis of HCMV genes is performed by constructing virus gene-deletion mutants and examining their growth phenotypes in different natural HCMV host cells. This systematic analysis of the HCMV genome identified 45 viral ORFs essential for viral replication and characterizes of 115 growth-dispensable viral genes. Of particular interest is the finding that HCMV encodes genes (temperance factors) that repress its own replication on a cell type-specific basis. In addition to HCMV, pathogen temperance may be a strategy employed by other infectious agents to enhance their long-term survivability within their respective host population.

REFERENCES:
Chee et al., Analysis of the Protein-Coding Content of the Sequence of Human Cytomegalovirus Strain AD169, (1990) Curr Top Microbiol Immunol, 154: 125-169.
Dargan et al., The Published DNA Sequence of Human Cytomegalovirus Strain AD169 Lacks 929 Base Pairs Affecting Genes UL42 and UL43, (1997), J Virol, 71 (12): 9833-9836.
Davison et al., The Human Cytomegalovirus Genome Revisited: Comparison With the Chimpanzee Cytomegalovirus Genome, (2003), J Gen Virol, 84: (Pt 1), 17-28.
Marchini et al., Human Cytomegalovirus With IE-2 (UL122) Deleted Fails to Express Early Lytic Genes, (2001), J Virol 75: 1870-8.

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