Cytomegalovirus disintegrin-like peptides

Details Cytomegalovirus disintegrin-like peptides Cytomegalovirus disintegrin-like peptides

2005-05-12

2009-02-17

Campell, Bruce (Department: 1648)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

C930S010000

Reexamination Certificate

active

07491490

ABSTRACT:
The present invention relates to methods and compositions for inhibiting the entry of viruses, such as herpesviruses into a host cell. A conserved viral integrin-binding gB disintegrin-like domain has been identified that engages integrins and facilitates viral internalization into the host cell. Therefore, methods and compositions, such as antiviral agents encompassing the conserved gB disintegrin-like domain and antibodies thereto are described. These active agents interfere with the interaction between virions and cellular integrins, thereby inhibiting viral infection of a host cell.

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