Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Bradykinin; kallidin; related peptides
Patent
1995-09-08
1998-12-15
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Bradykinin; kallidin; related peptides
C07K 9918
Patent
active
058498630
ABSTRACT:
The present invention provides bradykinin antagonists effective to inhibit cancer cell growth. Also provided are methods of inhibiting lung cancer cell growth by administering a therapeutically effective amount of a dimerized bradykinin antagonist.
REFERENCES:
patent: 4693993 (1987-09-01), Stewart et al.
patent: 5648336 (1997-07-01), Stewart et al.
patent: 5700779 (1997-12-01), Goodfellow et al.
Bunn, P. A., "Neuropeptide Signal Transduction in Lung Cancer: Clinical Implications of Bradykinin Sensitivity and Overall Heterogeneity," Cancer Res., 52, 24-31 (1992).
Bunn, P. A., et al., "Effects of Neuropeptide Analogues on Calcium Flux and Proliferation in Lung Cancer Cell Lines," Cancer Res., 54, 3602-3610 (1994).
Bunn, P. A., et al., "Neuropeptide Stimulation of Calcium Flux in Human Lung Cancer Cells: Delineation of Alternative Pathways," Proc. Natl. Acad. Sci. USA, 87, 2162-2166 (1990).
Cheronis, J. C., et al., "A New Class of Bradykinin Antagonists: Synthesis and In Vitro Activity of Bissuccinimidoalkane Peptide Dimers," J. Med. Chem., 35, 1563-1572 (1992).
Stewart, J. M., et al., "Bradykinin Chemistry: Agonists and Antagonists," In:Adv. Exp. Med. Biol., vol. 156, Fritz, H., (ed.), Plenum Press, New York, pp.585-589 (1983).
Vavrek, R. J., et al., "Succinyl Bis-Bradylinins: Potent Agonists with Exceptional Resistance to Enzymatic Degradation," In: Peptides--Structure and Function, Hruby, V. J., et al., (eds.), Pierce Chemical Company, Rockford, IL, pp.381-384 (1983).
Hawleys Condensed Chemical Dictionary, p. 1098 12th Edition (1993) "Suberic Acid".
Chan Daniel C.
Gera Lajos
Stewart John M.
Whalley Eric T.
Cortech Inc.
Delaney Patrick R.
Tsang Cecilia J.
University of Colorado
LandOfFree
Cytolytic bradykinin antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cytolytic bradykinin antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytolytic bradykinin antagonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1459009