Chemistry: analytical and immunological testing – Biological cellular material tested
Patent
1993-10-07
1994-10-04
Bhat, Nina
Chemistry: analytical and immunological testing
Biological cellular material tested
436 86, 436164, 436174, G01N 2159, G01N 3350
Patent
active
053526139
ABSTRACT:
A method and apparatus is provided, whereby the level of an intracellular analyte in a cell containing sample may be determined. The apparatus is comprised of a microscope with an X-Y stage, a video camera, a computer adapted to receive video images from the video camera, and a software program for controlling the apparatus in accordance with the method. The method provided performs digital image processing so as to cause undesired features of a video image obtained by the video camera to be diminished, while desired features are emphasized. A measurement of optical densities of desired features may then be used to determine the level of intracellular analyte.
REFERENCES:
patent: 4175860 (1979-11-01), Bacus
patent: 4400370 (1983-08-01), Kass
patent: 4523278 (1985-06-01), Reinhardt et al.
patent: 4615878 (1986-10-01), Kass
patent: 4675286 (1987-06-01), Calenoff
patent: 4741043 (1988-04-01), Bacus
patent: 4965725 (1990-10-01), Rutenberg
patent: 5000192 (1991-03-01), Sealfon
patent: 5004681 (1991-04-01), Boyse et al.
patent: 5008185 (1991-04-01), Bacus
patent: 5018209 (1991-05-01), Bacus
patent: 5073857 (1991-12-01), Peters et al.
patent: 5077806 (1991-12-01), Peters et al.
patent: 5109429 (1992-04-01), Bacus et al.
patent: 5153117 (1992-10-01), Simons
patent: 5192553 (1993-03-01), Boyse et al.
patent: 5204884 (1993-04-01), Leary et al.
patent: 5252487 (1993-10-01), Bacus et al.
"Measuring Unconjugated Estrolin Maternal Serum to Screen for Fetal Down Syndrome", Clin Chem 38/9, 1687-1689 (1992), Cuckle.
Lockett et al., Analytical and Quantitative Cytoloty and Histology, vol. 13, No. 1, pp. 29-44, Feb., 1991.
Lockett et al., Quantitative Precision of an Automated, Fluorescence-Based Image Cytometer, vol. 14, No. 3, pp. 187-202, Jun., 1992.
Lockett et al., Automated Image-Based Cytometry with Fluoroscence-Stained Specimens, BioTechniques, vol. 10, No. 4, pp. 514-519, 1991.
Poon, et al., Automated Image Detection and Segmentation in Blood Smears, Cytometry, vol. 13, pp. 766-774, 1992.
Neuromedical Systems, Inc., The breakthrough in automated Pap smear screening, 1989/1990, 5 pages.
Parthenis et al., Blood analysis using black and white digital images, J. Biomed. Eng., vol. 14, pp. 287-292, Jul., 1992.
Abstract: Sigma Diagnostics, Alkaline Phosphatase, Leukocyte, Procedure No. 86, Oct., 1990, 4 pages.
Media Cybernetics, Image-Pro Plus Manual, pp. 6-12-6-13, 6-39-8-43, A-21-A-23.
Clinical Chemistry, Measuring Unconjugated Estriol in Maternal Serum to Screeen For Fetal Down Syndrome, vol. 38, No. 9, 1992, pp. 1687-1689.
The Lancet, Urea-Resistant Neutrophil Alkaline Phosphatase in Mothers with Trisomy 21 Pregnancy, Oct. 1, 1983, pp. 799-800.
The Lancet, Semi-quantitative detection of Down's syndrome with PCR, vol. 340, Sep. 5, 1992, pp. 620-621.
Prenatal Diagnosis, First-Trimester Maternal Serum Biochemical Indicators in Down Syndrome, Prematal Diagnosis, vol. 10, 1990, pp. 245-251.
Prenatal Diagnosis, vol. 11, Cu/Zn Superoxide Dismutase Quantification from Fetal Erythrocytes-An Efficient Confirmatory Test for Down's Syndrome After Maternal Serum Screening and Sonographic Investigations, 1991, pp. 295-303.
Tafas Triantafillos P.
Tsipouras Petros
LandOfFree
Cytological screening method does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cytological screening method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytological screening method will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-580885