Cytokines that bind the cell surface receptor hek

Details Cytokines that bind the cell surface receptor hek Cytokines that bind the cell surface receptor hek

1995-05-30

1998-04-14

Ulm, John

Drug, bio-affecting and body treating compositions

Lymphokine

530351, 435 695, 435 697, 4352523, 4353201, 514 2, 514 8, 514 12, C07K 1452, A61K 3819

Patent

active

057388440

ABSTRACT:
Hek ligand (hek-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing hek-L polypeptides. The hek-L polypeptides bind to a cell surface receptor (hek) that is a member of the receptor tyrosine kinase family. Hek is expressed on cells that include certain tumor cell lines. The hek-L polypeptides also bind a distinct receptor tyrosine kinase known elk.

REFERENCES:
patent: 5185483 (1993-02-01), Lemischka
Bowie et al. (1990) Science vol. 247, pp. 1306-1310.
Cerretti et al., "Isolation of cDNAs that Encode Ligands to the Receptor Tyrosine Kinases Hek and Elk: Emergence of a Family of Proteins that are Ligands for the Eph Related Kinases (LERKS)", Abstract for American Assoc. for Cancer Research conference on Growth Factors, Development, and Cancer, held in Interlaken, Switzerland, Mar. 5-11, 1994.
Boyd et al., "Isolation and Characterization of a Novel Receptor-type Protein Tyrosine Kinase (hek) from a Human Pre-B Cell Line", J. Biol. Chem. 267:3262-3267, 1992.
Wicks et al., "Molecular Cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines", Proc. Natl. Acad. Sci. USA 89:1611-1615, 1992.
Wicks, "Molecular Characterisation of HEK, a Novel Human Receptor Tyrosine Kinase", Thesis for degree of Doctor of Philosophy, University of Melbourne, submitted Apr. 1992.
Lhotak et al., "Characterisation of Elk, a Brain-Specific Receptor Tyrosine Kinase", Mol. Cell. Biol. 11:2496-2502, 1991.
Letwin et al., "Novel protein-tyrosine kinase cDNAs related to fpslfes and eph cloned using anti-phosphotyrosine antibody", Oncogene 3:621-627, 1988.
Sajjadi et al., "Identification of a New eph-Related Receptor Tyrosine Kinase Gene From Mouse and Chicken That Is Developmentally Regulated and Encodes at Least Two Forms of the Receptor", New Biol. 3:769-788, 1991.
Chan and Watt, "eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases", Oncogene 6:1057-1061, 1991.
Lindberg et al., "cDNA Cloning and Characterization of eck, an Epithelial Cell Receptor Protein-Tyrosine Kinase in the eph/elk Family of Protein Kinases", Mol. Cell. Biol. 10:6316-6324, 1990.
Pasquale, "Identification of chicken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family", Cell Regulation 2:523-534, 1991.
Hirai et al., "A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene", Science 238:1717-1720, 1987.
Byrn et al., "Biological properties of a CD4 immunoadhesin", Nature 344:667-670, 1990.
Ashkenazi et al., "Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin", Proc. Natl. Acad. Sci. USA 88:10535-10539, 1991.
Holzman et al., "A Novel Immediate-Early Response Gene of Endothelium Is Induced by Cytokines and Encodes a Secreted Protein", Mol. Cell. Biol. 10:5830-5838, 1990.
Ferguson and Williams, "Cell-Surface Anchoring of Proteins via Glycosyl-Phosphatidylinositol Structures", Ann. Rev. Biochem. 57:285-320, 1988.
Bohme et al., "PCR mediated detection of a new human receptor-tyrosine-kinase, Hek 2", Oncogene 8:2857-2862, 1993.

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