Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1996-09-27
1998-10-13
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530412, 530416, 530417, 435 695, 435 701, 435 711, 435 712, 4351723, 435325, 4352523, 43525231, 43525234, 4352534, 43525411, 4352551, 4352552, 435366, C07K 1452, C12N 1563
Patent
active
058213368
ABSTRACT:
The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for the polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for the polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.
REFERENCES:
Bryant, J., et al., "Cloning and Expression of a Smooth Muscle Caldesmon", J. Biol. Chem., 264(23):13873-13879 (1989).
Burmeister, G., et al., "Generation and Characterization of a Monoclonal Antibody (IC5) to Human Migration Inhibitory Factor (MIF)", Immunobiol., 171:461-474 (1986).
Clemens, S., et al., Abstract Only, E.P. Appl. 162,812, "Lymphokine in the Pure State, Monoclonal Antibodies, Hybridoma Cell Lines, and Applications", Chemical Abstract, 104(25):223451q (1985).
Itakura, K., et al., "Synthesis and Use of Synthetic Oligonucleotides", Ann. Rev. Biochem., 53:323-356 (1984).
Lemaire, C., et al., "Nucleotide Sequence of Chicken Dystrophin cDNA", Nucleic Acids Research, 16(24):11815-11816 (1988).
Maniatis, et al., Molecular Cloning, A Laboratory Manual, 2nd Ed., 1.74-1.91, 7.12-7.15, 8.3-8.26, 8.46-8.52, 9.4-9.15, 15.3-15.4, 15.14-15.19, 15.51-15.52, 16.3-16.8 16.30-16.31, 16.8-16.16 (1989).
McNally, E., et al., "Complete Nucleotide Sequence of Full Length cDNA for Rat .alpha. Cardiac Myosin Heavy Chain", Nucleic Acids Research, 17(18):7527-7528 (1989).
Mellon, P., et al., "Identification of DNA Sequences Required for Transcription of the Human .alpha.1-Globin Gene in a New SV40 Host-Vector System", Cell, 27:279-288 (1981).
Molina, M.I. et al., "The Sequences of an Embryonic Myosin Heavy Chain Gene and Isolation of Its Corresponding cDNA", J. Biol. Chem., 262(14):6478-6488 (1987).
Odink, K., et al., "Two Calcium-binding Proteins in Infiltrate Macrophages of Reumatoid Arthritis", Nature, 330:80-82 (1987).
Odink, K.G., et al., Abstract Only, E.P. Appl. 263,072, "Cloning, Sequencing, and Expression of Macrophage Migration Inhibition Factor Genes, Preparation of Antibodies to the Proteins, and Use of the Antibodies for Diagnosis of Inflammatory Disorders and Cystic Fibrosis", Chemical Abstract, 109(17):1439662 (1988).
Roitt, I.M., et al., "Cellular Reactions in Delayed Hypersensitivity", Immunology, Gower Medical Publishing, London, 22.5-22.6 (1985).
Saez, L., et al., "Characterization of Diverse Forms of Myosin Heavy Chain Expressed in Adult Human Skeletal Muscle", Nucleic Acids Research, 14(7):2951-2969 (1986).
Shimokawa, Y., et al., Lymphocyte Chemotaxis in Inflammation: VII. Isolation and Purification of Chemotactic Factors for T Lymphocytes from PPD-Induced Delayed Hypersensitivity Skin Reaction Site in the Guinea-Pig, Immunology, 51(2):275-285 (1984).
Steinert, P.M., et al., "Molecular and Cellular Biology of Intermediate Filaments", Ann. Rev. Biochem., 57:593-625 (1988).
Ueda, K., et al., "The Chemical Mediation of Delayed Hypersensitivity Skin Reactions: III. Purification and Characterization of a Precursor Protein for Macrophage-Chemotactic Factor in Normal Guinea Pig Plasma", American Journal of Pathology, 108(3):291-298 (1982).
Weiser, W.Y., et al., "Molecular Cloning of a cDNA Encoding a Human Macrophage Migration Inhibitory Factor", PNAS, 86:7522-7526 (1989).
Young, R.A, "Efficient isolation of Genes by Using Antibody Probes", PNAS, 80:1194-1198 (1983).
Cunningham et al. (1989) Science vol. 244, pp. 1081-1085.
George et al. (1988) Macromolecular Sequencing & Synthesis chapter 12, pp. 127-149, Alan R. Liss, Inc., New York.
Bruggen Josef
Cerletti Nico
Delabie Jan
DeWolf-Peeters Christiane
Odink Karel Gerrit
Ferraro Gregory D.
Mertz Prema
Novartis Coporation
Ulm John
LandOfFree
Cytokine which mediates inflammation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cytokine which mediates inflammation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytokine which mediates inflammation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-314064