Cytokine which is a ligand for OX40

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

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530351, 530395, 514 12, C07K 14705

Patent

active

057836655

ABSTRACT:
There is disclosed a polypeptide (OX40-L) and DNA sequences, vectors and transformed host cells useful in providing OX40-L polypeptides. More particularly, this invention provides isolated murine OX40-L polypeptides that bind to the extracellular binding region of OX40.

REFERENCES:
Paterson et al., Mol. Immunol. 24:1281; 1987.
Mallett et al., EMBO J. 9:1063, 1990.
Mallett and Barclay, Immunlogy Today 12:220; 1991.
Smith et al., Biochem. Biophys. Res. Commun. 176:335; 1991.
Miura et al., Mol. Cell. Biol. 11:1313; 1991.
Calderhead et al., J. Immunol 151:5261-5271; 1993 (Nov.).

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