Cytokine suppressive anit-inflammatory drug binding proteins

Details Cytokine suppressive anit-inflammatory drug binding proteins Cytokine suppressive anit-inflammatory drug binding proteins

1994-05-31

1998-07-21

Fitzgerald, David L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530395, 435 691, 435194, C07K 14435, C07K 14705, C12N 1512, C12N 912

Patent

active

057836647

ABSTRACT:
This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein, to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.

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Cuenda, et al., "SB 203580 is a specific inhibitor of a Map kinase homologue which is stimulated by cellular stresses and interleukin-1", FEBS Letters, 364, pp. 229-233 (1995).
Lee, et al., "A protein kinase involved in the regulation of inflammatory cytokine biosynthesis" Nature, 372 22/29, pp. 739-746 (1994).
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Han et al. 1995. Biochimica et Biophisica Acta 1265:224-7.
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