Cytokine-, stress-, and oncoprotein-activated human protein kina

Details Cytokine-, stress-, and oncoprotein-activated human protein kina Cytokine-, stress-, and oncoprotein-activated human protein kina

1997-07-07

2000-10-24

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

536 232, 4352523, 4353201, 435194, C12N 912, C12N 1554, C12N 510, C12N 1563

Patent

active

061365963

ABSTRACT:
Disclosed are human mitogen-activated (MAP) kinase kinase isoforms (MKKs). MKKs mediate unique signal transduction pathways that activate human MAP kinases p38 and JNK, which result in activation of other factors, including activating transcription factor-2 (ATF2) and c-Jun. The pathways are activated by a number of factors, including cytokines and environmental stress. Methods are provided for identifying reagents that modulate MKK function or activity and for the use of such reagents in the treatment of MKK-mediated disorders.

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