Cytokine-, stress-, and oncoprotein-activated human protein kina

Details Cytokine-, stress-, and oncoprotein-activated human protein kina Cytokine-, stress-, and oncoprotein-activated human protein kina

1995-05-19

1998-09-08

Sisson, Bradley L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435183, 530350, C12N 912, C12N 900, C07K 100

Patent

active

058044272

ABSTRACT:
Disclosed are human mitogen-activated (MAP) kinase kinase isoforms (MKKs). MKKs mediate unique signal transduction pathways that activate human MAP kinases p38 and JNK, which result in activation of other factors, including activating transcription factor-2 (ATF2) and c-Jun. The pathways are activated by a number of factors, including cytokines and environmental stress. Methods are provided for identifying reagents that modulate MKK function or activity and for the use of such reagents in the treatment of MKK-mediated disorders.

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