Cytokine-, stress-, and oncoprotein-activated human protein kina

Details Cytokine-, stress-, and oncoprotein-activated human protein kina Cytokine-, stress-, and oncoprotein-activated human protein kina

1995-09-19

1998-04-07

Sisson, Bradley L.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 6, 435 911, 435 691, 435325, 4353201, 536 231, 536 235, 536 2431, 536 2433, 935 1, 935 8, 935 22, 935 66, C12N 120, C12N 1500, C07H 2104, C12P 2106

Patent

active

057363811

ABSTRACT:
Disclosed are human mitogen-activated (MAP) kinase kinase isoforms (MKKs). MKKs mediate unique signal transduction pathways that activate human MAP kinases p38 and JNK, which result in activation of other factors, including activating transcription factor-2 (ATF2) and c-Jun. The pathways are activated by a number of factors, including cytokines and environmental stress. Methods are provided for identifying reagents that modulate MKK function or activity and for the use of such reagents in the treatment of MKK-mediated disorders.

REFERENCES:
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