Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-11-12
1995-05-30
Warden, Jill
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 16, 514 17, 514 18, 530317, 530322, 530328, 530329, 530330, A61K 3800, C07K 500, C07K 700, C07K 1700
Patent
active
054201098
ABSTRACT:
The present invention provides novel cytokine restraining agents, which limit or control the biological activity of cytokines. The invention also provides pharmaceutical compositions comprising a cytokine restraining peptide and methods of administering the pharmaceutical composition to a subject. The invention further provides methods for using the novel peptides to restrain cytokine activity in a subject.
REFERENCES:
patent: 4457864 (1984-07-01), Hruby et al.
patent: 4485039 (1984-11-01), Hruby et al.
patent: 4649191 (1987-03-01), Hruby
patent: 4866038 (1989-09-01), Hruby et al.
patent: 4918055 (1990-04-01), Hruby et al.
patent: 5028592 (1991-07-01), Lipton
patent: 5049547 (1991-09-01), Hruby et al.
patent: 5157023 (1992-10-01), Lipton
Dinarello, Charles A. and Wolff, Sheldon, M. "The Role of Interleukin-1 in Disease." New England J. Med. 328:106-113 (1993).
Richard, D. B. and Lipton, J. M. "Effect of .alpha.-MSH 11-13 (Lysine-Proline-Valine) on Fever in the Rabbit." Peptides 5:815-817 (1984).
Deeter, L. B. et al. "Antipyretic Properties of Centrally Administered .alpha.-MSH Fragments in the Rabbit." Peptides 9:1285-1288 (1989).
Sugg, Elizabeth E. et al. "D-Isomeric Replacements Within the 6-9 Core Sequence of a Ac-[Nle.sup.4 ]-.alpha.-MSH.sub.4-11 -NH.sub.2 : A Topological Model for the Solution Conformation of a .alpha.-Melanotropin." Biopolymers 25:2029-2042 (1986).
Norlund, James J. ".alpha.-Melanocyte-Stimulating Hormone A Ubiquitous Cytokine with Pigmenting Effects." JAMA 266:2753-2754 (1991).
Levine, Norman et al. "Induction of Skin Tanning by Subcutaneous Administration of a Potent Synthetic Melanotropin." JAMA 266:2730-2736 (1991).
Al-Obeidi, Fahad et al. "Design of a New Class of Superpotent Cyclic .alpha.-Melanotrophins Based on Quenched Dynamic Simulations." J. Am. Chem. Soc. 111:3413-3416 (1989).
Poole, S. et al. "Peripheral Analgesic Activities of Peptides Related to .alpha.-Melanocyte Stimulating Hormone and Interleukin-1.beta..sup.193-195." Br. J. Pharmacol. 106:489-492 (1992).
Girten Beverly E.
Houghten Richard A.
Loullis Costas C.
Suto Mark J.
Tuttle Ronald R.
Houghten Pharmaceuticals, Inc.
Muff Sheera J.
Warden Jill
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