Cytokine polypeptides and antibodies containing a signal...

Details Cytokine polypeptides and antibodies containing a signal... Cytokine polypeptides and antibodies containing a signal...

2004-04-07

2009-12-01

Mertz, Prema (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S402000

Reexamination Certificate

active

07625998

ABSTRACT:
The invention relates to chimeric recombinant polypeptides, preferably therapeutic polypeptides, for example cytokines or antibodies, which are engineered to include a signal sequence for the attachment of glycosylphosphatidylinositol; cells expressing said polypeptides and methods to manufacture said polypeptides.

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Benting et al., “N-Glycans Mediate the Apical Sorting of a GPI-Anchored, Raft-Associated Protein in Madin-Darby Canine Kidney Cells,”J. Cell Biol. 146:313-320 (1999).
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Da Costa et al., “Production of the Thyrotrophin Receptor Extracellular Domain as a Glycosylphosphatidylinositol-Anchored Membrane Protein and Its Interaction with Thyrotrophin and Autoantibodies,”J. Biol. Chem. 273:11874-11880 (1998).
Guadiz et al., “The Carboxyl Terminus ofPneumocystis cariniiGlycoprotein A Encodes a Functional Glycosylphosphatidylinositol Signal Sequence,”J. Biol. Chem. 273:26202-26209 (1998).
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