Cytokine inhibitors

Details Cytokine inhibitors Cytokine inhibitors

2011-04-05

2011-04-05

Saeed, Kamal A (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C514S239200

Reexamination Certificate

active

07919617

ABSTRACT:
The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.

REFERENCES:
patent: 3546219 (1970-12-01), Long et al.
patent: 3626008 (1971-12-01), Biland
patent: 4029671 (1977-06-01), Friedman et al.
patent: 4761424 (1988-08-01), Carethers et al.
patent: 6143931 (2000-11-01), Baldino et al.
patent: 6197750 (2001-03-01), Karanewsky et al.
patent: 6452050 (2002-09-01), Baldino et al.
patent: 6525046 (2003-02-01), Cirillo et al.
patent: 6562558 (2003-05-01), Bealev et al.
patent: 6583282 (2003-06-01), Zhang et al.
patent: 6734301 (2004-05-01), Ennis et al.
patent: 6794380 (2004-09-01), Brown
patent: 6797267 (2004-09-01), Horwitz
patent: 2003/0008868 (2003-01-01), Francesco Cirillo et al.
patent: 2003/0060455 (2003-03-01), Moss et al.
patent: 2003/0068340 (2003-04-01), Cappola et al.
patent: 2003/0125354 (2003-07-01), Hao et al.
patent: 2003/0130309 (2003-07-01), Moss et al.
patent: 2003/0162968 (2003-08-01), Cirillo et al.
patent: 2003/0225089 (2003-12-01), Jung et al.
patent: 2003/0236193 (2003-12-01), Oliner et al.
patent: 2004/0023961 (2004-02-01), Dumas et al.
patent: 2004/0044020 (2004-03-01), Meade et al.
patent: 2004/0048797 (2004-03-01), Milleret et al.
patent: 2004/0110755 (2004-06-01), Simianer et al.
patent: 2004/0166111 (2004-08-01), Kaymakcalan et al.
patent: 2004/0192653 (2004-09-01), Munson et al.
patent: 2004/0192748 (2004-09-01), Barbosa, Jr. et al.
patent: 2004/0198697 (2004-10-01), Cohen et al.
patent: 2005/0107399 (2005-05-01), Boman et al.
patent: 2005/0176687 (2005-08-01), Moussy et al.
patent: 2010/0093735 (2010-04-01), Boman et al.
patent: 190457 (1986-08-01), None
patent: 00490263 (1992-06-01), None
patent: 514264 (1992-11-01), None
patent: 661260 (1995-07-01), None
patent: 747347 (1996-12-01), None
patent: 1022027 (2000-07-01), None
patent: 2834288 (2003-07-01), None
patent: 05201980 (1993-08-01), None
patent: 07224041 (1995-08-01), None
patent: 2001031636 (2001-02-01), None
patent: 2003335733 (2003-11-01), None
patent: WO 92/06948 (1992-04-01), None
patent: WO 98/09946 (1998-03-01), None
patent: WO 98/46551 (1998-10-01), None
patent: WO 98/46559 (1998-10-01), None
patent: WO 99/23091 (1999-05-01), None
patent: WO 99/32110 (1999-07-01), None
patent: WO 99/32463 (1999-07-01), None
patent: WO 99/51224 (1999-10-01), None
patent: WO 99/55696 (1999-11-01), None
patent: WO 99/64044 (1999-12-01), None
patent: WO 00/16769 (2000-03-01), None
patent: WO 00/18725 (2000-04-01), None
patent: WO 00/18738 (2000-04-01), None
patent: WO 00/43384 (2000-07-01), None
patent: WO 00/50425 (2000-08-01), None
patent: WO 00/55151 (2000-09-01), None
patent: WO 01/01986 (2001-01-01), None
patent: WO 01/10821 (2001-02-01), None
patent: WO 01/12187 (2001-02-01), None
patent: WO 01/12189 (2001-02-01), None
patent: WO 01/36403 (2001-05-01), None
patent: WO 01/47913 (2001-07-01), None
patent: WO 01/47916 (2001-07-01), None
patent: WO 01/55144 (2001-08-01), None
patent: WO 01/58869 (2001-08-01), None
patent: WO 02/08225 (2002-01-01), None
patent: WO 02/32862 (2002-04-01), None
patent: WO 02/42248 (2002-05-01), None
patent: WO 02/42292 (2002-05-01), None
patent: WO 02/006644 (2002-08-01), None
patent: WO 02/072571 (2002-09-01), None
patent: WO 02/083628 (2002-10-01), None
patent: WO 02/085859 (2002-10-01), None
patent: WO 02/092576 (2002-11-01), None
patent: WO 02/096876 (2002-12-01), None
patent: WO 02/098869 (2002-12-01), None
patent: WO 03/000680 (2003-01-01), None
patent: WO 03/005999 (2003-01-01), None
patent: WO 03/010159 (2003-02-01), None
patent: WO 03/022273 (2003-03-01), None
patent: WO 03/049742 (2003-06-01), None
patent: WO 03/068221 (2003-08-01), None
patent: WO 03/068223 (2003-08-01), None
patent: WO 03/072569 (2003-09-01), None
patent: WO 03/084539 (2003-10-01), None
patent: WO 2004/004725 (2004-01-01), None
patent: WO 2004/013127 (2004-02-01), None
patent: WO 2004/022041 (2004-03-01), None
patent: WO 2004/024727 (2004-03-01), None
patent: WO 2004/045607 (2004-06-01), None
patent: WO 2004/058724 (2004-07-01), None
patent: WO 2004/083193 (2004-09-01), None
Abjil, Atherosclerose en ontsteking: de betekenis van C-reactieve proteine. Ned Tijdschr Geneeskd, 2003,147(1),15-20.
Ablamunits, et. al., Islet T Cells Secreting IFN-y in NOD Mouse Diabetes: Arrest by p277 Peptide Treatment: J. Autoimmun., 1988, 11, 73-81.
Abu-Amer, et. al., Tumor Necrosis Factor Receptors Types 1 and 2 Differentially Regulate Osteoelastogenesis: J. Biol. Chem., 2000, 275(35), 27307-10.
Akaike, et. al., Free radicals in viral pathogenesis: molecular mechanisms involving superoxide and NO: Proc. Soc: Exp. Biol. Med., 1998,217,64-73.
Alexander, et. al., Mechanisms of innate resistance toToxoplasma gondiiinfection: Philos. Trans. R. Soc. Lond. B. Biol. Sci., 1997,352, 1355-1359.
Aliev et al., Synthesis and structure of 5-p-ethoxypheny1-3-methoxycarbonyl-1-p-tolyl-4-ptolyloxamoylpyrazole. Russian Chemical Bulletin (Translation of Izvestiya Akademil Nauk, Seriya Khimicheskaya), 48(3): 604-607, 1999.
Bacqui, et. al., “Enhanced Interleukin-1J3, Interleukin-6 and Tumor Necrosis Factor-a Production By LPS Stimulated Human Monocytes Isolated From HIV+ Patients,” Immunopharmacol. Immunotoxicol, 2000,22(3),401-421.
Baronzio, et. al., ProinfJammatory and regulatory cytokine levels in AIDS cachexia: In Vivo, 1999, 13(6),499-502.
Barry, et. al., A Molecular Rearrangement During the Reduction of Thionaphthenopyrazole Dioxides: J. Chem. Soc., 1956,4974-4978.
Bartens and Pusch, Oxindigo, Dibenzo-4,5,4′,5′ and dibenzo-6,7,6′,7,-oxindigo. Ann. 442:254-305, 1925. (English Abstract of a Section of Reference C46—Fries below).
Beisel. “Herman Award Lecture, 1995: infection-induced malnutrition-from cholera to cytokines,” Am. J. Clin. Nutr., 1995.62,813-819.
Ben-Bassat, Biological activity of tyrosine kinase inhibitors: Novel agents for psoriasis therapy,n Current Opinion in Investigational Drugs, 2001,2(11), 1539-1545.
Bodor, “Novel Approaches In Prodrug Design,” Drugs of the Future, 1981,6,165-182.
Bonay. “Characterization of proliferative responses and cytokine mRNA profiles induced byVespulavenom in patients with severe reactions to wasp stings,” Clin. Exp. Immunol., 1997, 109,342-350.
Borjesson, et. al., TNF-a stimulates alveolar liquid clearance during intestinal ischemia-reperfusion in rats, Amer. J. Physiol., 2000, 278, L-3-L12.
Bozkurt, “Results of Targeted Anti-Tumor Necrosis Factor Therapy With Etanercept (ENBREL) in Patients With Advanced Heart Failure,” Circulation, Feb. 27, 2001, 103(8) 1044-1047.
Branger, et. al.. “Anti-Inflammatory Effects of a p38 Mitogen-Activated Protein Kinase Inhibitor During Human Endotoxemia,” J. Immunol.. 2002, 168(8) 4070-4.
Bresnihan. et. al., Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist, Arthritis. Rheum., 1998. 41 :2196-2204.
Bruserud, “Effects of Endogenous Interleukin 1 on Blast Cells Derived From Acute Myelognoeus Leukemia Patients,” Leukemia Res., 1996,20,65-73.
Burke, et. al., “Early Development of Acute Myelogenous Leukemia Following Kidney Transplantation: Possible Role of Multiple Serum Cytokines,” Leuk. Lymphoma., 1995, 19, 173-180.
Chen et al., Rapid synthesis of a-ketoamides using microwave irradiation-simultaneous cooling method. Tetrahedron Lett., 44:8873-8876. 2003.
Chevalier, “Upregulation of enzymatic activity by interleukin-1 in osteoarthritis,” Biomed. Pharmacother., 1997, 51, 58-62.
Childs, “Efficacy of Etanercept for Wear Debris -Induced Osteolysis,” J. Bone Miner. Res., 2001, 16, 338-347.
Chisari, et. al., “Hepatitis B virus immunology,” Sprinter Semin. Immunopathol., 1995, 17,261-281.
Clarmunt, et. al., “3(5)-(I-Adamantyl)pyrazoles: chem

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