Cytokine designated 4-IBB ligand

Details Cytokine designated 4-IBB ligand Cytokine designated 4-IBB ligand

1994-05-06

1997-10-07

Walsh, Stephen

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 536 235, 530350, C12N 1512, C12N 1563, C07K 14705

Patent

active

056747047

ABSTRACT:
Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and host cells transformed with the recombinant expression vectors are disclosed, along with methods for producing the novel polypeptides by cultivating such transformed host cells. Soluble forms of the 4-1BB-L or 4-1BB polypeptides are derived from the extracellular domains thereof.

REFERENCES:
patent: 4675285 (1987-06-01), Clark et al.
patent: 5030576 (1991-07-01), Dull et al.
patent: 5217880 (1993-06-01), Mitta et al.
patent: 5312733 (1994-05-01), MacLeod
Kwon and Weissman, "cDNA sequences of two inducible T-cell genes," Proc. Nat. Acad. Sci. 86:1963-1967, 1989.
Kwon et al., "Expression Characteristics of Two Potential T Cell Mediator Genes," Cellular Immunology 121:414-422, 1989.
Kwon et al., "Isolation and initial characterization of multiple species of T-lymphocyte subset cDNA clones," Proc. Natl. Acad. Sci. 84:2896-2900, 1987.
Pollok et al., "Inducible T Cell Antigen 4-IBB," Journal of Immunology, 150:771-781 1993.
Mallett and Barclay, "A new superfamily of cell surface proteins related to the nerve growth factor receptor," Immunology Today, 12:220-223, 1991.
Schwarz et al., "cDNA Sequence Tissue Distribution and Regulation of Expression of a New Member of the Human TNF-NGF Receptor Family," Arthritis Rheum., 35 (9 Suppl.), Abstract D63, p. S224, 1992.
Schwarz et al., "Identification of a New Member of the Human Nerve Growth Factor/Tumor Necrosis Factor Receptor Family ," J. Immunol., 150:298A, Abstract No. 1705, 1993.
Chalupny et al., "T-cell activation molecule 4-1BB binds to extracellular matrix proteins," Proc. Natl. Acad. Sci. 89:10360-10364, 1992.
Flanagan and Leder, "The kit Ligand: A Cell Surface Molecule Altered in Steel Mutant Fibroblasts," Cell 63:185-194, 1990.
Aruffo and Seed, "Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system," Proc. Natl. Acad. Sci. 84:8573-8577, 1987.
Capon et al., "Designing CD4 immunoadhesins for AIDS therapy," Nature 337:525-531, 1989.
R. E. Steele, "Factor hunting made easier," TIBS 16:125-126, 1991.
Armitage et al., Nature 357:80-82, 1992.
Hollenbaugh et al., EMBO J. 11:4313-4321, 1992.
Goodwin et al., "Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor", Eur. J. Immunol. 23:2631-2641, 1993.
Schwartz et al., "A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family", Gene 134:295-298, 1993.
Ohtsuka et al., "An Alternative Approach to Deoxyoligonucleotides as Hybridization Probes by Insertion of Deoxyinosine at Ambiguous Codon Positions," J. of Biol. Chem. 260:(5):2605-2608, 1985.
Frohman et al., "Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer," Proc. Natl. Acad. Sci. U.S.A., 85:8998-9002, 1988.

Affiliated with

Also associated with

Rating

Cytokine designated 4-IBB ligand does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cytokine designated 4-IBB ligand, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytokine designated 4-IBB ligand will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2356136