Cytokine activity regulator molecules from tick salivary glands

Details Cytokine activity regulator molecules from tick salivary glands Cytokine activity regulator molecules from tick salivary glands

2002-08-12

2008-10-21

Tate, Christopher R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C435S184000, C435S320100

Reexamination Certificate

active

07439229

ABSTRACT:
The present invention relates to cytokine activity regulator molecules (CARMs) and their use in controlling the action of cytokines, particularly chemokines. In particular, the invention relates to CARMs that are derived from parasite salivary glands. The invention also relates to the use of CARMs in the treatment of diseases and allergies and in the production of vaccines that protect mammals, including humans, against the transmission of pathogenic (disease-causing) micro-organisms by certain parasites.

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Brown et al. , Experimental Parasitology, 1986, vol. 62, pp. 40-50.
Wang, et al., (1999), Molecular individuality: polymorphism of salivary gland proteins in three species of ixodid tick, Experimental and Applied Acarology, 23:969-975.
Brown and Askenase, (1986), Amblyomma americanum: Physiochemical Isolation of a Protein Derived from the Tick Salivary Gland that is Capable of Inducing Immune Resistance in Guinea Pigs, Experimental Parasitology, 62:40-50.
Yang, et al., (1999), Fully human anti-interleukin-8 monoclonal antibodies: potential therapeutics for the treatment of inflammatory disease states, Journal of Leukocyte Biology, 66:401-410.
Titus & Gillespie, (1999), T-Cell Activation and Signaling, Faseb Journal, 13:A954, Abstract No. 704.53, XP-000881956.

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