Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1985-01-30
1988-10-04
Marantz, Sidney
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 29, 435 68, 4351722, 435810, 436519, 436548, 436813, 530387, 530828, 935110, G01N 3353, G01N 33574, G01N 33577
Patent
active
047756209
ABSTRACT:
Methods and compositions are provided for identifying patients suffering from neoplastic diseases such as breast cancer. It has been found that neoplastic epithelial cells, including neoplastic mammary epithelial cells, release a particular N-terminal blocked, soluble cytokeratin into circulation. The presence of this cytokeratin is diagnostic of neoplastic disease.
REFERENCES:
patent: 4229426 (1980-10-01), Haagensen
Brabon et al. (1983) Monoclonal Antibodies to Estrogen Sensitive Proteins in Human Breast Cancer Cells, Abstract presented at Breast Cancer Research Conference, Mar. 20-24, 1983, Internat'l. Assoc. Breast Ca. Research.
Karsten et al. (1983) Monoclonal Antibodies Against Antigens of the Human Mammary Carcinoma Cell Line MCF-7, Abstract Arch Geschwulstforsch 53(6): 529-536.
Moll et al. (1982) The Catalog of Human Cytokeratins: Patterns of Expression in Normal Epithelial, Tumors and Cultured Cells, Cell 31: 11-24.
Debus et al. (1982) Monoclonal Cytokeratin Antibodies that Distinguish Simple from Stratified Squamous Epithelia: Characterization on Human Tissues , Eur. Mol. Biol. Organ. 1(12): 1641-1648, Biol. Abstr. 76(4): 29367.
Debus et al. (1984) Immunohistochemical Distinction of Human Carcinomas by Cytokeratin Typing with Monoclonal Antibodies, Am. J. Pathol. 114(1): 121-130, Biol. Abstr. 77(11): 84821.
Van Muijen et al. (1984) Monoclonal Antibodies with Different Specificities Against Cytokeratins: An Immunochemical Study of Normal Tissues and Tumors, Am. J. Pathol. 114(1): 9-17, Biol. Abstr. 77(12): 93017.
Krepler et al. (1981) Keratin-Like Proteins in Normal and Neoplastic Cells of Human and Rat Mammary Gland as Revealed by Immunofluorescence Differ. 20(3) 242-252.
Krepler et al. (1982) Antibodies to Intermediate Filament Proteins as Molecular Markers in Clinical Tumor Pathology, Differentiation of Carcinomas by Their Reaction with Different Cytokeratin Antibodies, Pathol. Res. Pract. 175(2): 212-226 (Abstr.).
Coggi et al. (1982) Cytokeratin Immunohistochemistry in Human Neoplastic Cells, Biol. Cell 45(2):202 (Abstr.).
Kohler and Milstein (1975) Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity, Nature 256:495-497.
Westley and Rochefort (1980) Cell 20:3353-3362.
Veith et al. (1983) Cancer Res. 43:1861-1868.
Ciocca et al. (1982) Cancer Res. 42:4256-4258.
Wagner et al. (1982) Aust. N.Z.J. Surg. 52:41-43.
Mross et al. (1983) Klin. Wochenschr. 61:461-468.
Mairesse et al. (1981) J. Steroid Biochem. 15:375-381.
Madri et al. (1983) Lab. Invest. 48:98-107.
F. Ramaekers et al. (1981) Use of Antibodies to Intermediate Filaments in the Characterization of Human Tumors, Cold Spring Harb. Symp. Quant. Biol. 46:331-340.
M. Osborn et al. (1982) Intermediate Filaments: Cell-Type-Specific Markers in Differentiation and Pathology, Cell 31:303-306.
M. Osborn et al. (1984) Conventional and Monoclonal Antibodies to Intermediate Filament Proteins in Human Tumor Diagnosis In: Cancer Cells 1, The Transformed Phenotype, Cold Spring Harbor Laboratory, pp. 191-200.
T. T. Sun et al. (1984) Classification, Expression and Possible Mechanisms of Evolution of Mammalian Keratins: A Unifying Model In: Cancer Cells 1, The Transformed Phenotype, Cold Spring Harbor Laboratory, pp. 169-176.
M. Osborn et al. (1984) Uses of Conventional and Monoclonal Antibodies to Intermediate Filament Proteins in the Diagnosis of Human Tumors, (Proc. 4th Internat. Expert Meeting of the Deutsche Stiftung fuer Krebsforschung.) In: Genes and Antigens in Cancers Cells-The Monoclonal Antibody Approach, Contributions to Oncology 19:148-159.
B. Luening et al. (1983) Sequence Homology Between Tissue Polypeptide Antigen (TPA) and Intermediate Filament (IF) Proteins, Acta. Chem. Scand. Ser. B 37:731-733.
P. Redelius et al. (1980) Chemical Studies of Tissue Polypeptide Antigen (TPA), II. Partial Amino Acid Sequences of Cyanogen Bromide Fragments of TPA Subunit B.sub.1 1, Acta Chemica, Scandinavica B 34:265-273.
J. A. Madri et al. (1983) Methods in Laboratory Investigation, Use of Avidin-Biotin Complex in an ELISA System: A Quantitative Comparison with Two Other Immunoperoxidase Detection Systems Using Keratin Antisera, Lab. Invest. 48:98-0107.
M. Altmannsberger et al. (1981) The Distribution of Keratin Type Intermediate Filaments in Human Breast Cancer, Virchows Arch. (Cell Pathol.) 37:277-284.
W. W. Franke et al. (1981) Diversity of Cytokeratins, Differentiation Specific Expression of Cytokeratin Polypeptides in Epithelial Cells and Tissues, J. Mol. Biol. 153:933-959.
F. C. S. Ramaekers et al. (1983) Antibodies to Intermediate Filament Proteins in the Immunohistochemical Identification of Human Tumors: An Overview, Histochem. J. 15:691-713.
F. Ramaekers et al. (1983) Monoclonal Antibody to Keratin Filaments, Specific for Glandular Epithelia and Their Tumors: Use in Surgical Pathology, Lab. Invest 49:353-361.
J. Viac et al. (1983) Reactivity Pattern of a Monoclonal Antikeratin Antibody (KL1), J. Invest. Dermat. 81:351-354.
Brabon Alan C.
Cardiff Robert D.
Rossitto Paul V.
Marantz Sidney
The Regents of the University of California
LandOfFree
Cytokeratin tumor markers and assays for their detection does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cytokeratin tumor markers and assays for their detection, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytokeratin tumor markers and assays for their detection will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2156126