Cytochrome P450 oxygenases and their uses

Details Cytochrome P450 oxygenases and their uses Cytochrome P450 oxygenases and their uses

2006-02-28

2006-02-28

Achutamurthy, Ponnathapu (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

C435S004000, C435S006120, C435S252300, C435S320100, C435S069100, C435S071100, C435S440000, C435S410000, C435S419000, C536S023100, C536S023200, C536S023700

Reexamination Certificate

active

07005283

ABSTRACT:
Oxygenase enzymes and the use of such enzymes to produce paclitaxel (Taxol™), related taxoids, as well as intermediates in the Taxol biosynthetic pathway are disclosed. Also disclosed are nucleic acid sequences encoding the oxygenase enzymes.

REFERENCES:
patent: WP 98 40470 (1989-09-01), None
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Eisenreich et al.,Multiple Oxygenase Reactions in the Biosynthesis of Taxoids, J. Am. Chem. Soc., 120:37, pp. 9694-9695, Sep. 23, 1998.
Hefner et al.,Cytochrome P450-Catalyzed Hydroxylation of Taxa-4(5),11(12)-diene to Taxa-4(20),11(12)-dien-5 α-ol: The First Oxygeneration Step in Taxol Biosynthesis, Chemistry & Biology, vol. 3, pp. 479-489, Jun. 1996.
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Schoendorf et al.,Molecular Cloning of a Cytochrome P450 Taxane 10β-Hydroxylase cDNA From Taxus and Functional Expression in Yeast, Proceedings of the National Academy of Science USA, 98:4, pp. 1501-1506, Feb. 13, 2001.
Tsumura et al.,Sequence-Tagged-Sites(STSs)of cDNA clones in Cryptomeria Japonica and their Evaluation as Molecular Markers in Conifers, Theor. Appl. Genet., vol. 94, pp. 764-772, (1997).
Wildung et al.,A cDNA Clone for Taxadiene Synthase, the Diterpene Cyclase that Catalyzes the Committed Step of Taxol Biosynthesis, The Journal of Biological Chemistry, 271:16, pp. 9201-9204, Apr. 19, 1996.

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