Cytochrome P450 monooxygenases consisting of thermophilic...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase

Reexamination Certificate

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C435S004000, C435S006120, C435S440000, C435S252300, C435S320100, C435S069100, C435S071100, C435S132000, C536S023200

Reexamination Certificate

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07553648

ABSTRACT:
The invention relates to novel cytochrome P450 monooxygenases from thermophilic bacteria, in particular the genusThermussp., to nucleotide sequences encoding them, to the recombinant production of these monooxygenases and to their use for the microbiological oxidation of organic compounds.

REFERENCES:
patent: 2379518 (2001-01-01), None
patent: 2378615 (2001-02-01), None
patent: 2380186 (2001-02-01), None
Zamorano et al., GenBank accession No. CAB77247, Oct. 2000.
Henne et al. The genome sequence of the extreme thermophile Thermus thermophilus. Nat. Biotechnol. 22:547-553(2004).
Ruettinger et al. Coding nucleotide, 5′ regulatory, and deduced amino acid sequences of P-450BM-3, a single peptide cytochrome P-450:NADPH-P-450 reductase fromBacillus megaterium. J. Biol. Chem. 264 (19), 10987-10995 (1989).
Branden et al. Introduction to Protein Structure, Garland Publishing Inc., New York, p. 247, 1991.
Guo et al. Proc Natl Acad Sci USA. Jun. 22, 2004;101(25):9205-10.

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