Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-03-27
2007-03-27
Fredman, Jeffrey (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S023200, C536S024330
Reexamination Certificate
active
10712363
ABSTRACT:
A primer set used to screen a polynucleotide sample to detect and identify variants in the Cytochrome P450 isoenzyme 2D6 (CYP2D6) gene. A method of screening a polynucleotide sample to detect and identify the presence of one or more than one variant in the CYP2D6 gene in the sample. A method of predicting the potential for altered metabolism of a substance, including one or more than one pharmaceutical drug, by a first individual compared to a second control individual, where the substance is metabolized by the CYP2D6 isoenzyme, and where the second control individual is homozygous for the wild type allele of the CYP2D6*1, SEQ ID NO:1. A method of screening a population to detect and identify the presence of one or more than one variant in the CYP2D6 gene. A purified or isolated variant of SEQ ID NO:1. A purified or isolated variant of SEQ ID NO:3.
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GenBank Accession No. M33388 (1994). 5 pages. Accessed Aug. 9, 2006.
Buck et al. Design strategies and performance of custom DNA sequencing primers. Biotechniques (1999) 27: 528-536.
Longo et al. Use of uracil DNA glycosylase to control carry-over contamination in polymerase chain reactions. Gene (1990) 93(1): 125-128.
Bertagna Angela
Bioventures, Inc.
Farah David A.
Fredman Jeffrey
Sheldon Mak Rose & Anderson PC
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