Cytochrome P-450 monooxygenases

Details Cytochrome P-450 monooxygenases Cytochrome P-450 monooxygenases

1999-02-24

2000-10-17

Riley, Jezia

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

530350, 435 4, 435440, 435468, 800278, 800288, C12Q 100, C12Q 126, G01N 3353, C07H 1900

Patent

active

061334170

ABSTRACT:
New cytochrome P-450 dependent monooxygenases and DNA molecules encoding these monooxygenases are provided, which are able to catalyze the biosynthetic pathway from amino acids to their corresponding cyanohydrins, the presursors of the cyanogenic glycosides, or to glucosinolates. Moreover, the invention provides methods for obtaining DNA molecules according to the invention and methods for obtaining transgenic plants resistant to insects, acarids, or nematodes or plants with improved nutritive value.

REFERENCES:
patent: 5882851 (1999-03-01), Koch et al.
Sibbesen et al. "Isolation of the heme-thiolate enzyme cytochrome P-450Tyr, which catalysis the committed step in the biosynthesis of teh cyanogenic glucoside dhurrin in Sorghum bicolor (L.)Moench" Proc. Natl. Acad. Sci. USA, vol. 91, pp. 9740-9744, Oct. 1994.
Gabriac, et al., "Purification and Immunocharacterization of a Plant Cytochrome P450: The Cinnamic Acid 4-Hydroxylase", Archives of Biochemistry and Biophysics, 288(1): 302-309 (1991).
Halkier et al., "The Biosynthesis of Cyanogenic Glucosides in Higher Plants", The Journal of Biological Chemistry, 264(33): 19487-19494 (1989).
Halkier, et al., "Biosynthesis of the Cyanogenic Glucoside Dhurrin in Seedlings of Sorghum bicolor (L.) Moench and Partial Purification of the Enzyme System Involved", Plant Physiol., 90: 1552-1559 (1989).
Halkier, et al., "Cyanogenic glucosides: the biosynthetic pathway and the enzyme system involved", Department of Plant Physioology, Royal Veterinary and Agricultural University, 40: 49-66 (1988).
Halkier, et al., "The Biosynthesis of Cyanogenic Glucosides in Higher Plants", The Journal of Biological Chemistry, 265(34): 21114-21121 (1990).
Halkier, et al., "Involvement of Cytochrome P-450 in the Biosynthesis of Dhurrin in Sorghum bicolor (L.) Moench", Plant Physiol., 96: 10-17 (1991).
Halkier, et al., "2-Nitro-3-(.rho.-hydroxyphenyl)propionate and aci-1-nitro-2-(.rho.-hydroxyphenyl)ethane, two intermediates in the biosynthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor (L.) Moench", Proc. Natl. Acad. Sci., 88: 487-491 (1991).
Koch, et al., "The biosynthesis of cyanogenic glucosides in seedlings of cassava (Manihot esculenta Crantez),", Archives of Biochemistry and Biophysics, 292: 141-150 (1992).
Sibbesen et al., "Purification of the Hydroxylating Enzyme System Involved in the Biosynthesis of the Cyanogenic Glucoside Dhurrin in Sorghum Bicolor (l.) Moench", Biochemistry and Biophysics of Cytochrome P450, 232 (1991).

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