Cytochalasin and isoindolinone derivatives as inhibitors of angi

Details Cytochalasin and isoindolinone derivatives as inhibitors of angi Cytochalasin and isoindolinone derivatives as inhibitors of angi

1998-03-17

1999-11-30

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514417, 514418, 514419, 548472, 548473, 548480, 548481, A61K 3140, C07D20946, C07D20958

Patent

active

059943882

ABSTRACT:
The present invention relates to inhibition of angiogenesis and the treatment of diseases mediated by angiogenesis. Particularly, the invention relates to the inhibition of neovascularization and the treatment of cancer. The invention further relates to the use of cytochalasin derivatives for the inhibition of angiogenesis and the treatment of angiogenesis associated diseases. The invention also relates to new isoindolinone compounds, compositions containing them, and methods of inhibiting angiogenesis and treating angiogenesis associated diseases with the isoindolinone derivatives.

REFERENCES:
patent: 3849437 (1974-11-01), Ousby et al.
patent: 5593990 (1997-01-01), D'Amato
Algire, G.H. et al., "Vascular reactions of normal and malignant tumors in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants", J. Natl. Canc. Inst., vol. 6, pp. 73-85 (1945).
Angiolillo, A.l. et al., "Human interferon-inducible Protein 10 is a potent inhibitor of angiogenesis in vivo", J. Exp. Med., vol. 182, pp. 155-162 (1995).
Brem, H. et al., "Intestinal chemotherapy with drug polymer implants for the treatment of recurrent gliomas", J. Neurosurg., vol. 74, pp. 441-446 (1991).
Brenner, et al., "The Effects of Cytochalasins on Actin Polymerization and Actin ATPase Proved Insights into the Mechanism of Polymerization", The J. Biol. Chem., vol. 255, No. 3, pp. 841-844 (1980).
Buchi, G. et al., "Structure of Cytochalasin E, a Toxic Metabolite of Aspergillus clavatus", J.A.C.S., vol. 95, pp. 5423-5425 (1973).
Cao, Y. et al., "gro-.beta., .alpha.-C-X-C-Chemokine, Is an Angiogenesis Inhibitor That Suppresses the Growth of Lewis Lung Carcinoma in Mice", J. Esp. Med., vol. 182, pp. 2069-2077 (1995).
Carter, S.B., "Effects of Cytochalasins on Mammalian Cells", Nature, vol. 213, No. 5073, pp. 261-264 (1967).
Chen, C. et al., "A A Strategy to Discover Circulating Angiogenesis Inhibitors Generated by Human Tumors", Canc. Res., vol. 55, pp. 4230-4233 (1995).
Clapp, C. et al., "The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis", Endocrinology, vol. 133, pp. 1292-1299 (1993).
Dameron, K.M. et al., "Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1", Science, vol. 265, pp. 1582-1584 (1994).
Flanagan, M.D. et al., "Cytochalasins Block Actin Filament Elongation by Binding to High Affinity Sites Associated with F-actin", The J. Biol. Chem., vol. 255, No. 3, pp. 835-838 (1980).
Folkman, J., "Tumor angiogenesis and tissue factor", Nature Med., vol. 2, pp. 167-168 (1996).
Folkman, J., "What is the Evidence that Tumors are Angiogenesis Dependent?", J. Natl. Canc. Inst., vol. 82, pp. 4-6 (1990).
Folkman, J., "Angiogenesis in cancer, vascular, rheumatoid and other disease", Nature Medicine, vol. 1, No. 1, pp. 27-31 (1995).
Folkman, J., "Long-term culture of capillary endothelial cells", Proc. Natl. Acad. Sci. USA 76, pp. 5217-5221 (1979).
Folkman, J., "Induction of angiogenesis during the transition from hyperplasia to neoplasia", Nature, vol. 339, pp. 58-61 (1989).
Folkman, J., "Tumor Behavior in Isolated Perfused Organs In Vitro Growth and Metastases of Biopsy Material in Rabbit Thyroid and Canine Intestinal Segment", Annals of Surgery, vol. 164, No. 3, pp. 491-501 (1966).
Folkman, J., "Angiogenesis and Its Inhibitors", Important Advances in Oncology, J.B. Lippincott Company, pp. 42-62 (1985).
Folkman, J., "Tumor Angiogenesis Therapeutic Implications", NE J. of Med., No. 18, pp. 1182-1186 (1971).
Gavrieli, Y. et al., "Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation", J. Cell Biol., vol. 119, pp. 493-501 (1992).
Gimbrone, M.A. et al., "Tumor Growth and Neovascularization An Experimental Model using the Rabbit Cornea", J. Natl. Canc. Inst., vol. 52, No. 2, pp. 413-427 (1974).
Gimbrone, M.A. et al., "Tumor Dormancy in Vivo by Prevention of Neovascularization", J. of Exper. Med., vol. 136, pp. 261-276 (1972).
Glinsukon, T. et al., "Acute and Subacture Toxicity of Cytochalasin E in the Rat", Toxicology and Applied Pharmacology, vol. 32, pp. 135-146 (1975).
Good, D.J. et al., "A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin", Proc. Nat. Acad. Sci. USA, vol. 87, pp. 6624-6628 (1990).
Grant, D.S. et al., "Scatter factor induces blood vessel formation in vivo", Proc. Natl. Acad. Sci. USA, vol. 99, pp. 1937-1941 (1993).
Grant, D.S. et al., "Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro", Cell, vol. 58, pp. 933-943 (1989).
Gross, J.L. et al., "Modulation of Solid Tumor Growth in vivo by bFGF", Proc. Amer. Assoc. Canc. Resh, vol. 31, p. 79 (1990) (Abstract).
Gross, J.L. et al., "Increase capillary endothelial cell protease activity in response to angiogenic stimuli in vitro", Proc. Natl. Acad. Sci. USA, vol. 80, pp. 2623-2627 (1983).
Grumet, et al., "Reversal of Profilin Inhibition of Actin Polymerization In Vitro by Erthrocyte Cytochalasin-Binding Complexes and Cross-Linked Actin Nuclei", Biochem. and Biophys. Res. Comm., vol. 92, No. 4, pp. 1327-1334 (1980).
Gupta, S.K. et al., "A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4", Proc. Natl. Acad. Sci. USA, vol. 92, pp. 7779-7803 (1995).
Holmgren, L. et al., "Dormancy of micrometastases Balanced proliferation and apoptosis in the presence of angiogenesis suppression", Nature Med., vol. 1, No. 2, pp. 149-153 (1995).
Homandberg, G.A. et al., "Heparin-binding fragments of fibronectin are potent inhibitors of endothelial cell growth", Am. J. Path., vol. 120, pp. 327-332 (1985).
Hori, A. et al., "Suppression of Solid tumor Growth by Immunoneutralizing Monoclonal Antibody against Human Basic Fibroblast Growth Factor", Canc. Res., vol. 51, pp. 6180-6184 (1991).
Ingber, D. et al., "Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor growth", Nature, vol. 348, pp. 555-557 (1990).
Kajimoto, T. et al., "Nuclear Magnetic Resonance Studies of Cytochalasin E and Its Decomposition Product", Chem. & Pharm. Bull., vol. 37, No. 8, pp. 2212-2213 (1989).
Kandel, J. et al., "Neovascularization is Associated with a Switch to the Expert of bFGF in the Multistep Development of Fibrosarcoma", Cell, vol. 66, pp. 1095-1104 (1991).
Kim, K.J. et al., "Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo", Nature, vol. 362, pp. 841-844 (1993).
Knighton, D. et al., "Avascular and Vascular Phases of Tumor Growth in the Chick Embryo", Br. J. Cancer, vol. 35, pp. 347-356 (1977).
Lein, W. M. et al., "The blood supply of experimental liver metastases. II. A Microcirculatory study of the normal and tumor vessels of the liver with the use of perfused silicone rubber", Surgery, vol. 68, No. 2, pp. 334-340 (1970).
Lerch et al., "Localization of Individual Lysine-Binding Regions in Human Plasminogen and Investigations on Their Complex-Forming Properties", European Journal of Biochemistry, vol. 107, No. 1, pp. 7-13 (1980).
Lin, et al.,"On the Mechanism for Inactivation of Cytochalasin Binding Activity Associated with F-Actin and Spectrin-Band 4.1-Actin Complex by Sulfhydryl Reagents", Biochem. and Biophys. Res. Comm., vol. 122, No. 1, pp. 244-251 (1984).
Maione, T.E. et al., "Inhibition of Angiogenesis by Recombinant Hum,an Platelet Factor-4 and Related Peptiddes", Science, vol. 247, pp. 77-79 (1990).
McPherson, et al., "Inhibition of DNA Synthesis in Adrenocortical Cells by Cytochalasin B", The Journal of Cell Biology, vol. 86, pp. 129-134 (1980).
Millauer, B. et al., "Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant", Nature, vol. 367, pp. 576-579 (1994).
Mookerjee, et al., "Cytochalasin Effects on Lymphocytes", The J. Biol. Chem., vol. 256, No. 3, pp. 1291-1300 (1981).
Moses, M.A. et al., "Identification of an Inhibitor of Neovascularization from Cartilage", Science, vol. 248 (1990).
Muragaki, Y. et al., "Mouse col 18a1 is e

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