Cytarabine ocfosfate hard capsule

Details Cytarabine ocfosfate hard capsule Cytarabine ocfosfate hard capsule

1993-03-24

1996-04-30

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424451, 514 49, 5147723, 514778, 514781, 514908, A61K 948, A61K 31505

Patent

active

055122981

ABSTRACT:
The present invention relates to hard capsules of cytarabine ocfosfate which is useful as an anti-leukemia drug applicable to oral administration.
By providing the cytarabine ocfosfate hard capsule comprising (1) cytarabine ocfosfate, (2) a high molecular compound functioning as a disintegrator and (3) an alkali, there can be provided pharmaceutical preparations having excellent disintegration property and stability. The cytarabine ocfosfate hard capsules are applicable to clinical use.

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patent: 5049663 (1991-09-01), Terada et al.
patent: 5223503 (1993-06-01), Gossett et al.
Gennaro et al., "Remington's Pharmaceutical Sciences", Ionic Solutions and Electrolytic Equilibria: Pharmaceutical Significance, Chapter 17, Eighteenth Edition, 1990, pp. 245-246.
Remington's Pharmaceutical Sciences, pp. 1607 and 1625, 1985.
Chemical Abstracts, vol. 109, No. 12, 19 Sep. 1988, Columbus, Ohio, US; abstract No. 98727j, John E. Botzolakis et al.
Chemical Abstracts, vol. 103, No. 8, 26 Aug. 1985, Columbus, Ohio, US; Abstract No. 59243e, P. De Beukelaer et al.

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