Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Reexamination Certificate
2006-12-19
2006-12-19
Solola, Taofiq (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
C544S317000
Reexamination Certificate
active
07151092
ABSTRACT:
Compounds of Formula I, their preparation and uses are described:wherein:M and V are cis to one another and MH is cytarabine;the 5′ oxygen of said cytarabine is attached to the phosphorus;V is 4-pyridyl;and pharmaceutically acceptable prodrugs and salts thereof.
REFERENCES:
patent: 3018302 (1962-01-01), Bielefeld et al.
patent: 3116282 (1963-12-01), Hunter
patent: 3328388 (1967-06-01), Shen et al.
patent: 4440740 (1984-04-01), Fix et al.
patent: 4692441 (1987-09-01), Alexander et al.
patent: 4729989 (1988-03-01), Alexander et al.
patent: 4731360 (1988-03-01), Alexander et al.
patent: 4749694 (1988-06-01), Fix et al.
patent: 4822773 (1989-04-01), Alexander et al.
patent: 4835138 (1989-05-01), Alexander et al.
patent: 4847298 (1989-07-01), Alexander et al.
patent: 4952740 (1990-08-01), Juge et al.
patent: 4963525 (1990-10-01), Alexander et al.
patent: 4963556 (1990-10-01), Alexander et al.
patent: 4973579 (1990-11-01), Alexander et al.
patent: 5077280 (1991-12-01), Sommadossi et al.
patent: 5118672 (1992-06-01), Schinazi et al.
patent: 5159067 (1992-10-01), Schinazi et al.
patent: 5437772 (1995-08-01), De Castro et al.
patent: 5464748 (1995-11-01), Sommadossi et al.
patent: 5567689 (1996-10-01), Sommadossi et al.
patent: 5599686 (1997-02-01), DeFeo-Jones et al.
patent: 5658889 (1997-08-01), Gruber et al.
patent: 5663159 (1997-09-01), Starrett, Jr. et al.
patent: 5723449 (1998-03-01), Sommadossi et al.
patent: 5750493 (1998-05-01), Sommadossi et al.
patent: 5854231 (1998-12-01), Camden
patent: 5866679 (1999-02-01), DeFeo-Jones et al.
patent: 5948750 (1999-09-01), Garsky et al.
patent: 5990093 (1999-11-01), Schinazi et al.
patent: 6037335 (2000-03-01), Takashima et al.
patent: 6054587 (2000-04-01), Reddy et al.
patent: 6110903 (2000-08-01), Kasibhatla et al.
patent: 6130504 (2000-10-01), Nakayama et al.
patent: 6143864 (2000-11-01), DeFeo-Jones et al.
patent: 6177404 (2001-01-01), DeFeo-Jones et al.
patent: 6194391 (2001-02-01), Schinazi et al.
patent: 6245749 (2001-06-01), Schinazi et al.
patent: 6284748 (2001-09-01), Dang et al.
patent: 6294672 (2001-09-01), Reddy et al.
patent: 6312662 (2001-11-01), Erion et al.
patent: 6391305 (2002-05-01), Feng et al.
patent: 6395716 (2002-05-01), Gosselin et al.
patent: 6399782 (2002-06-01), Kasibhatla et al.
patent: 6407077 (2002-06-01), Gosselin et al.
patent: 6444652 (2002-09-01), Gosselin et al.
patent: 6458773 (2002-10-01), Gosselin et al.
patent: 6486204 (2002-11-01), Waldstreicher et al.
patent: 6489476 (2002-12-01), Dang et al.
patent: 6525033 (2003-02-01), Schinazi et al.
patent: 6545007 (2003-04-01), Sommadossi et al.
patent: 6566344 (2003-05-01), Gosselin et al.
patent: 6569837 (2003-05-01), Gosselin et al.
patent: 6596700 (2003-07-01), Sommadossi et al.
patent: 6602664 (2003-08-01), Schinazi et al.
patent: 6635636 (2003-10-01), Artico et al.
patent: 6752981 (2004-06-01), Erion et al.
patent: 6946115 (2005-09-01), Erion et al.
patent: 2001/0041713 (2001-11-01), Waldstreicher et al.
patent: 2002/0115596 (2002-08-01), Gosselin et al.
patent: 2002/0120130 (2002-08-01), Gosselin et al.
patent: 2002/0147160 (2002-10-01), Bhat et al.
patent: 2002/0193415 (2002-12-01), Sommadossi et al.
patent: 2003/0050229 (2003-03-01), LaColla et al.
patent: 2003/0060400 (2003-03-01), LaColla et al.
patent: 2003/0083306 (2003-05-01), Imbach et al.
patent: 2003/0225277 (2003-12-01), Kopcho et al.
patent: 2003/0229225 (2003-12-01), Reddy et al.
patent: 2003/0232760 (2003-12-01), Garsky et al.
patent: 2004/0006002 (2004-01-01), Sommadossi et al.
patent: 2004/0006007 (2004-01-01), Gosselin et al.
patent: 2004/0192651 (2004-09-01), Reddy et al.
patent: 2005/0101776 (2005-05-01), Gosselin et al.
patent: 2005/0288240 (2005-12-01), Erion et al.
patent: 0161955 (1985-11-01), None
patent: 0180276 (1986-05-01), None
patent: 0338372 (1989-10-01), None
patent: 0353692 (1995-10-01), None
patent: 0481214 (1998-06-01), None
patent: 2266525 (1993-11-01), None
patent: 2266527 (1999-03-01), None
patent: 6511420 (1966-03-01), None
patent: WO 91/19721 (1991-12-01), None
patent: WO 95/07287 (1995-03-01), None
patent: WO 95/07920 (1995-03-01), None
patent: WO 96/01267 (1996-01-01), None
patent: WO 97/03679 (1997-02-01), None
patent: WO 97/49717 (1997-12-01), None
patent: 99/45016 (1999-09-01), None
patent: WO00/03998 (2000-01-01), None
patent: WO00/009531 (2000-02-01), None
patent: WO 00/52015 (2000-09-01), None
patent: WO01/090121 (2001-11-01), None
patent: WO01/92282 (2001-12-01), None
patent: WO02/083126 (2002-10-01), None
patent: WO03/026589 (2003-04-01), None
patent: WO03/026675 (2003-04-01), None
patent: WO04/002422 (2004-01-01), None
patent: WO04/002999 (2004-01-01), None
patent: WO04/0003000 (2004-01-01), None
Aleksiuk et al.,J. Chem. Soc. Chem. Comm. (1)11, (1993).
Arner et al.,Pharmacol. Ther. 67(2):155-86, (1995).
Attansi et al.,Phosphorus Sulfur35(1-2), 63 (1988).
Ayral-Kaloustian et al.,Carbohydr. Res. 187 (1991).
Bhatia et al.,Tetrahedron Lett. 28(3), 271 (1987).
Chu et al.,J. Het. Chem. 22:1033 (1985).
Coppi et al.J. Org. Chem. 53:911 (1988).
DeWaziers et al.,J. Pharm. Exp. Ther., 253, 387-394 (1990).
Dyatkina et al.,Tetrahedron Lett. 35(13), 1961 (1994).
Ferroni et al.,J. Org. Chem. 64(13), 4943 (1999).
Fuji et al.,J. Am. Chem. Soc. 118(10):2521-2 (1996).
Gao, et al.,J. Org. Chem. 53:4081 (1980).
Greene, T.W.,Protective Groups in Organic Chemistry, John Wiley & Sons, New York (1999) (outline only).
Gorenstein et al.,J. Am. Chem. Soc. 5077 (1980).
Gish et al.,J.Med. Chem. 14, 1159 (1971).
Hadvary et al.,Helv. Chim. Acta69(8), 1862 (1986).
Hanaoka et al.,Heterocycles23(11), 2927 (1985).
Harada et al,Tetrahedron Lett. 28:4843 (1987).
Hayakawa et al.,Tetrahedron Lett. 28(20), 2259 (1987).
Hessler,J. Org. Chem. 41(10):1828-1831 (1976).
Hoefler et al.,Tetrahedron56(11), 1485 (2000).
Hulst et al.,Tetrahedron Lett. 1339 (1993).
Jacobsen, E.N. et al.,Comprehensive Asymmetric Catalysis(1999) (outline only).
Kobayashi et al.,Tetrahedron Lett. 27:4745 (1986).
Li et al.,Tetrahedron Lett. 6615 (2001).
March, J.Advanced Organic Chemistry, McGraw Hill Book Company, New York, (1977 edition) pp. 251-259.
Meek et al.,J. Am, Chem Soc. 110(7), 2317 (1988).
Merckling et al.,Tetrahedron Lett. 2217 (1996).
Mosbo et al., .,J. Org. Chem. 42, 1549 (1977).
Mukaiyama,Org. React. 28:203 (1982).
Noyori, R. et al.,Asymmetric Catalysis on Organic Synthesis(1994) (list of content only).
Postel et al.,J. Carbohyd. Chem. 19(2), 171 (2000).
Ramachandran et al.,Tetrahedron Lett. 38:761 (1997).
Rathore et al.,Indian J. Chem B. 32(10), 1066 (1993).
Roodsari et al.,J. Org. Chem. 64(21), 7727 (1999).
Sakamoto et al., Tetrahedron Lett. 33:6845 (1992).
Shen et al.,J. Org. Chem. 30:835-838 (1965).
Shirai, et al.,Bioorg. Med. Chem. Lett. 88:1997-2000 (1998).
Stromberg et al.,J. Nucleot. 6(5), 815 (1987).
Takaku et al.,Chem. Lett. (5) 699 (1986).
Torneiro et al.,J. Org. Chem. 62(18), 6344 (1997).
Turner et al.,J. Org. Chem. 54:4229 (1989).
Turner et al.,J. Org. Chem. 55:4744 (1990).
Van Haperen, Ruiz et al.,Semin Oncol. 22 Suppl. 11(4):35-41 (1995).
Vankayalapati et al.,J. Chem. Soc. Perk T /14, 2187 (2000).
Wechter et al.,J. Med. Chem., 19(8), 1013 (1976).
Yamamoto et al.,Tetrahedron Lett. 37:1871 (1981).
Braess, J. et al. “Oral Cytarabine Octosfate in Acute Myeloid Leukemia and non-Hodgkin's Lymphoma—Phase I/II Studies and Pharmacokietics”,Leukemia12:1618-1626, Stockton Press (1998).
Chabner, B.A., “Cytidine Analogues”, inCancer Chemotherapy: Principles and Practice, Lippincott Williams & Wilkins (Apr. 1990).
Chabner, B.A., et al., “Purification and Properties of Cytidine Deaminase from Normal and Leukemic Granulocytes”,Journal of Clinical Investigation53:922-931, American Society for Clinical Investigation (Mar. 1974).
Cohen, S.S. “The Mechanisms of Lethal Action of Arabinosyl Cytosine (araC) and Arabinosyl Adenine (araA)”,Cancer40:509-518, Wiley (1977).
Grant, S., “Biochemical Modulation of Cytosine Arabinoside”,Pharmac. Ther. 48:29-44, Pergamon Press plc (1990).
Leach, W.B. et al. “Toxicity Studies i
Boyer Serge
Erion Mark D.
Metabasis Therapeutics, Inc.
Solola Taofiq
Sterne Kessler Goldstein & Fox P.L.L.C.
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