Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2006-06-27
2006-06-27
Kerr, Kathleen (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
C435S252300
Reexamination Certificate
active
07067286
ABSTRACT:
Recombinant host cells of the suborder Cystobacterineae, genusStizmatella, containing recombinant expression vectors that encode heterologous epothilone polyketide synthase (PKS) genes and can produce epothilones at high levels are provided.
REFERENCES:
patent: 4916138 (1990-04-01), Ueda et al.
patent: 5605793 (1997-02-01), Stemmer
patent: 5672491 (1997-09-01), Khosla et al.
patent: 5686295 (1997-11-01), Jaoua et al.
patent: 5712146 (1998-01-01), Khosla et al.
patent: 5776735 (1998-07-01), Denoya et al.
patent: 5783431 (1998-07-01), Petersone et al.
patent: 5811238 (1998-09-01), Stemmer et al.
patent: 5824513 (1998-10-01), Katz et al.
patent: 5830721 (1998-11-01), Stemmer et al.
patent: 5830750 (1998-11-01), Khosla et al.
patent: 5843718 (1998-12-01), Khosla et al.
patent: 5969145 (1999-10-01), Schinzer et al.
patent: 6022731 (2000-02-01), Khosla et al.
patent: 6033883 (2000-03-01), Barr et al.
patent: 6090601 (2000-07-01), Gustafsson et al.
patent: 6121029 (2000-09-01), Schupp et al.
patent: 6242469 (2001-06-01), Danishefsky et al.
patent: 6300355 (2001-10-01), Danishefsky et al.
patent: 6303342 (2001-10-01), Julien et al.
patent: 6346404 (2002-02-01), Schupp et al.
patent: 6355457 (2002-03-01), Schupp et al.
patent: 6355458 (2002-03-01), Schupp et al.
patent: 6355459 (2002-03-01), Schupp et al.
patent: 6358719 (2002-03-01), Schupp et al.
patent: 6383787 (2002-05-01), Schupp et al.
patent: 6391594 (2002-05-01), Khosla et al.
patent: 6410301 (2002-06-01), Julien et al.
patent: 6489314 (2002-12-01), Ashley et al.
patent: 6583290 (2003-06-01), Julien et al.
patent: 6589968 (2003-07-01), Arslanian et al.
patent: 2003/0045711 (2003-03-01), Ashley et al.
patent: 2003/0073205 (2003-04-01), Arslanian et al.
patent: 41 38 042 (1993-05-01), None
patent: 0423714 (1994-06-01), None
patent: 0428169 (1995-03-01), None
patent: WO 93/10121 (1993-05-01), None
patent: WO 97/02358 (1997-01-01), None
patent: WO 97/13845 (1997-04-01), None
patent: WO 97/19086 (1997-05-01), None
patent: WO 98/08849 (1998-03-01), None
patent: WO 98/22461 (1998-05-01), None
patent: WO 98/25929 (1998-06-01), None
patent: WO 98/27203 (1998-06-01), None
patent: WO 98/49315 (1998-11-01), None
patent: WO 99/01124 (1999-01-01), None
patent: WO 99/02514 (1999-01-01), None
patent: WO 99/02669 (1999-01-01), None
patent: WO 99/03986 (1999-01-01), None
patent: WO 99/07692 (1999-02-01), None
patent: WO 99/43320 (1999-02-01), None
patent: WO 99/15047 (1999-04-01), None
patent: WO 99/27890 (1999-06-01), None
patent: WO 99/39694 (1999-08-01), None
patent: WO 99/40047 (1999-08-01), None
patent: WO 99/42602 (1999-08-01), None
patent: WO 99/43653 (1999-09-01), None
patent: WO 99/54318 (1999-10-01), None
patent: WO 99/54319 (1999-10-01), None
patent: WO 99/54330 (1999-10-01), None
patent: WO 99/65913 (1999-12-01), None
patent: WO 99/66028 (1999-12-01), None
patent: WO 99/67252 (1999-12-01), None
patent: WO 99/67253 (1999-12-01), None
patent: WO 00/00485 (2000-01-01), None
patent: WO 00/01838 (2000-01-01), None
patent: WO 00 22139 (2000-04-01), None
patent: WO 00/31247 (2000-06-01), None
patent: WO 01/083800 (2001-11-01), None
patent: WO 02/080846 (2002-10-01), None
An, J. and Kim, Y. (1998).Eur J Biochem274(52):395-402.
Balog D., et al. (1996).Angew Chem Int Ed Engl35 (23/24):2801-2803.
Balog, D. et al. (1998).Angew Chem Int Ed Engl37 (19):2675-2678.
Betlach, et al. (1998).Biochem37:14937.
Beyer et al., Biochimica et Biophysica Acta (1999) 1445:185-195.
Bierman, et al. (1992).Gene116:43-49.
Bollag, D. et al. (1995).Cancer Res55:2325-2333.
Campos ans Zusman, (1975).Proc Natl Acad Sci USA72:518-522.
Campos, et al. (1978).J Mol Biol119:167-168.
Caspers, et al.(1994).Cellular and Molecular Biology40(5):635-644.
Chou, T.C. et al. (1998).Natl Acad Sci USA95 (16):9642-9647.
Gerth, K. et al. (1996).J Antibiotics49:560-563.
Hahn D., et al.. (1991).J. Bact173:5573-5577.
Hamilton, C. et al. (1989).J Bact171(9):4617-4622.
Hodgkin and Kaiser. (1979).Mol Gen Genet171:177-191.
Hofle, et al. (1996).Angew Chem Int Ed Engl35(13/14):1567-1569.
Hondo, T. et al. (1987).Transplantation ProceedingsX1X(5) Suppl 6:17-22.
Jacobsen, et al. (1998).Biochemistry37:4928-4934.
Jaoua, et al. (1992).Plasmid28:157-165.
Kafeshi, et al. (1995).Mol Microbiol15:483-494.
Kaiser, (1979). Proc.Natl Acad Sci USA76:5952-5956.
Katz, et al. (1983).J Gen Microbiol129:2703-2714.
Keiser and Melton, (1988).Gene65:83-91.
Link, A. et al. (1997).J Bact179(20):6228-6237.
Lydiate, et al. (1985).Gene35:223-235.
Magrini, et al. (1999).J Bact181 (13):4062-4070.
Meng, et al. (1997).JACS119 (42):10073-10092.
Molnar, I. et al. (2000).Chemistry&Biology7 (2):97-109.
Muth, et al. (1989).Mol Gen Genet219:341-348.
Nicolaou, et al. (1997).Angew Chem Int Ed Engl36:2097-2103.
Oliynyk et al., Chemistry & Biology (1996) 3:833-839.
Paitan et al., J. Molecular Biology (1999) 286:465-474.
Salmi, et al. (1998).J Bact180 (3):614-621.
Scholz, et al. (1989).Gene75:271-278.
Servin-Gonzales, (1993).Plasmid30:131-140.
Sheng, et al. (1995).Nucleic Acids Res23:1990-1996.
Silakowski, B. et al. (1990).J Biol Chem274(52):37391-37399.
Smokvina, et al. (1990).Gene94:53-59.
Stassi, et al. (1998).Appl Micribiol Biotechnol49:725-731.
Strong, S. et al. (1997).Nucleic Acids Res19:3959-3961.
Su, et al. (1997).Angew Chem Int Ed Engl36 (19): 2093-2096.
Su, et al. (1997).Angew Chem Int Ed Engl36 (7):757-759.
Tang, L. et al. (2000).Science287:640-642.
Thompson, et al. (1982).Gene20:51-62.
Ueki, T. et al. (1996). Gene 183:153-157.
Vara, et al. (1989).J Bacteriol171:5782-5791.
Varon et al., Antimircrobial Agents and Chemotherapy (1992) 36 (10):2316-2321.
Witkowski, et al. (1999).Biochem38(36): 11643-11650.
Wu and Kaiser. (1997).J Bact179 (24):7748-7758.
Arslanian, R.L. et al. (2002). “Large-Scal Isolation and Crystallization of Epothilone D fromMyxococcus Xanthus Cultures,” J. Natural Products65(4):570-572.
Bretscher, A.P. et al. (1978). “Nutrition ofMyxococcus Xanthus, a Fruiting Myxobacterium,”J. Bacteriology133(2):763-768.
Frykman, S. et al. (2002). “Modulation of Epothilone Analog Production Through Media Design, ”J. Industrial Microbiology & Biotechnology28(1):17-20.
Lau, J. et al (2002). “Optimizing the Heterologous Production of Epothilone D inMyxococcus Xanthus, ” Biotechnology and Bioengineering78(3):280-288.
Nicolaou, K.C. et al. (1998). “Chemical biology of epothilones,”Angew Chem Int Ed37(15):2014-2045.
Pfeifer, B. A. et al. (2001). “Biosynthesis of polyketides in heterologous hosts,”Microbiology and Molecular Biology Reviews65(1):106/118.
Regentin, R. et al. (2001). “Development of a cost effective epothilone D process inmyxococcus xanthus, ” Abstracts of Papers American Chemical Society221(1-2):BIOT 61.
Shimkets, L.J. (1993). “Chapter 12: Industrial relevance and genetic analysis of myxobacteria,”Industrial Microorganisms: Basic and Applied Molecular Genetics 5thASM pp. 85-96.
Julien Bryan
Katz Leonard
Khosla Chaitan
Kerr Kathleen
Kosan Biosciences, Inc.
Townsend and Townsend / and Crew LLP
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