Cystobacterineae host cells containing heterologous PKS...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S252300

Reexamination Certificate

active

07067286

ABSTRACT:
Recombinant host cells of the suborder Cystobacterineae, genusStizmatella, containing recombinant expression vectors that encode heterologous epothilone polyketide synthase (PKS) genes and can produce epothilones at high levels are provided.

REFERENCES:
patent: 4916138 (1990-04-01), Ueda et al.
patent: 5605793 (1997-02-01), Stemmer
patent: 5672491 (1997-09-01), Khosla et al.
patent: 5686295 (1997-11-01), Jaoua et al.
patent: 5712146 (1998-01-01), Khosla et al.
patent: 5776735 (1998-07-01), Denoya et al.
patent: 5783431 (1998-07-01), Petersone et al.
patent: 5811238 (1998-09-01), Stemmer et al.
patent: 5824513 (1998-10-01), Katz et al.
patent: 5830721 (1998-11-01), Stemmer et al.
patent: 5830750 (1998-11-01), Khosla et al.
patent: 5843718 (1998-12-01), Khosla et al.
patent: 5969145 (1999-10-01), Schinzer et al.
patent: 6022731 (2000-02-01), Khosla et al.
patent: 6033883 (2000-03-01), Barr et al.
patent: 6090601 (2000-07-01), Gustafsson et al.
patent: 6121029 (2000-09-01), Schupp et al.
patent: 6242469 (2001-06-01), Danishefsky et al.
patent: 6300355 (2001-10-01), Danishefsky et al.
patent: 6303342 (2001-10-01), Julien et al.
patent: 6346404 (2002-02-01), Schupp et al.
patent: 6355457 (2002-03-01), Schupp et al.
patent: 6355458 (2002-03-01), Schupp et al.
patent: 6355459 (2002-03-01), Schupp et al.
patent: 6358719 (2002-03-01), Schupp et al.
patent: 6383787 (2002-05-01), Schupp et al.
patent: 6391594 (2002-05-01), Khosla et al.
patent: 6410301 (2002-06-01), Julien et al.
patent: 6489314 (2002-12-01), Ashley et al.
patent: 6583290 (2003-06-01), Julien et al.
patent: 6589968 (2003-07-01), Arslanian et al.
patent: 2003/0045711 (2003-03-01), Ashley et al.
patent: 2003/0073205 (2003-04-01), Arslanian et al.
patent: 41 38 042 (1993-05-01), None
patent: 0423714 (1994-06-01), None
patent: 0428169 (1995-03-01), None
patent: WO 93/10121 (1993-05-01), None
patent: WO 97/02358 (1997-01-01), None
patent: WO 97/13845 (1997-04-01), None
patent: WO 97/19086 (1997-05-01), None
patent: WO 98/08849 (1998-03-01), None
patent: WO 98/22461 (1998-05-01), None
patent: WO 98/25929 (1998-06-01), None
patent: WO 98/27203 (1998-06-01), None
patent: WO 98/49315 (1998-11-01), None
patent: WO 99/01124 (1999-01-01), None
patent: WO 99/02514 (1999-01-01), None
patent: WO 99/02669 (1999-01-01), None
patent: WO 99/03986 (1999-01-01), None
patent: WO 99/07692 (1999-02-01), None
patent: WO 99/43320 (1999-02-01), None
patent: WO 99/15047 (1999-04-01), None
patent: WO 99/27890 (1999-06-01), None
patent: WO 99/39694 (1999-08-01), None
patent: WO 99/40047 (1999-08-01), None
patent: WO 99/42602 (1999-08-01), None
patent: WO 99/43653 (1999-09-01), None
patent: WO 99/54318 (1999-10-01), None
patent: WO 99/54319 (1999-10-01), None
patent: WO 99/54330 (1999-10-01), None
patent: WO 99/65913 (1999-12-01), None
patent: WO 99/66028 (1999-12-01), None
patent: WO 99/67252 (1999-12-01), None
patent: WO 99/67253 (1999-12-01), None
patent: WO 00/00485 (2000-01-01), None
patent: WO 00/01838 (2000-01-01), None
patent: WO 00 22139 (2000-04-01), None
patent: WO 00/31247 (2000-06-01), None
patent: WO 01/083800 (2001-11-01), None
patent: WO 02/080846 (2002-10-01), None
An, J. and Kim, Y. (1998).Eur J Biochem274(52):395-402.
Balog D., et al. (1996).Angew Chem Int Ed Engl35 (23/24):2801-2803.
Balog, D. et al. (1998).Angew Chem Int Ed Engl37 (19):2675-2678.
Betlach, et al. (1998).Biochem37:14937.
Beyer et al., Biochimica et Biophysica Acta (1999) 1445:185-195.
Bierman, et al. (1992).Gene116:43-49.
Bollag, D. et al. (1995).Cancer Res55:2325-2333.
Campos ans Zusman, (1975).Proc Natl Acad Sci USA72:518-522.
Campos, et al. (1978).J Mol Biol119:167-168.
Caspers, et al.(1994).Cellular and Molecular Biology40(5):635-644.
Chou, T.C. et al. (1998).Natl Acad Sci USA95 (16):9642-9647.
Gerth, K. et al. (1996).J Antibiotics49:560-563.
Hahn D., et al.. (1991).J. Bact173:5573-5577.
Hamilton, C. et al. (1989).J Bact171(9):4617-4622.
Hodgkin and Kaiser. (1979).Mol Gen Genet171:177-191.
Hofle, et al. (1996).Angew Chem Int Ed Engl35(13/14):1567-1569.
Hondo, T. et al. (1987).Transplantation ProceedingsX1X(5) Suppl 6:17-22.
Jacobsen, et al. (1998).Biochemistry37:4928-4934.
Jaoua, et al. (1992).Plasmid28:157-165.
Kafeshi, et al. (1995).Mol Microbiol15:483-494.
Kaiser, (1979). Proc.Natl Acad Sci USA76:5952-5956.
Katz, et al. (1983).J Gen Microbiol129:2703-2714.
Keiser and Melton, (1988).Gene65:83-91.
Link, A. et al. (1997).J Bact179(20):6228-6237.
Lydiate, et al. (1985).Gene35:223-235.
Magrini, et al. (1999).J Bact181 (13):4062-4070.
Meng, et al. (1997).JACS119 (42):10073-10092.
Molnar, I. et al. (2000).Chemistry&Biology7 (2):97-109.
Muth, et al. (1989).Mol Gen Genet219:341-348.
Nicolaou, et al. (1997).Angew Chem Int Ed Engl36:2097-2103.
Oliynyk et al., Chemistry & Biology (1996) 3:833-839.
Paitan et al., J. Molecular Biology (1999) 286:465-474.
Salmi, et al. (1998).J Bact180 (3):614-621.
Scholz, et al. (1989).Gene75:271-278.
Servin-Gonzales, (1993).Plasmid30:131-140.
Sheng, et al. (1995).Nucleic Acids Res23:1990-1996.
Silakowski, B. et al. (1990).J Biol Chem274(52):37391-37399.
Smokvina, et al. (1990).Gene94:53-59.
Stassi, et al. (1998).Appl Micribiol Biotechnol49:725-731.
Strong, S. et al. (1997).Nucleic Acids Res19:3959-3961.
Su, et al. (1997).Angew Chem Int Ed Engl36 (19): 2093-2096.
Su, et al. (1997).Angew Chem Int Ed Engl36 (7):757-759.
Tang, L. et al. (2000).Science287:640-642.
Thompson, et al. (1982).Gene20:51-62.
Ueki, T. et al. (1996). Gene 183:153-157.
Vara, et al. (1989).J Bacteriol171:5782-5791.
Varon et al., Antimircrobial Agents and Chemotherapy (1992) 36 (10):2316-2321.
Witkowski, et al. (1999).Biochem38(36): 11643-11650.
Wu and Kaiser. (1997).J Bact179 (24):7748-7758.
Arslanian, R.L. et al. (2002). “Large-Scal Isolation and Crystallization of Epothilone D fromMyxococcus Xanthus Cultures,” J. Natural Products65(4):570-572.
Bretscher, A.P. et al. (1978). “Nutrition ofMyxococcus Xanthus, a Fruiting Myxobacterium,”J. Bacteriology133(2):763-768.
Frykman, S. et al. (2002). “Modulation of Epothilone Analog Production Through Media Design, ”J. Industrial Microbiology & Biotechnology28(1):17-20.
Lau, J. et al (2002). “Optimizing the Heterologous Production of Epothilone D inMyxococcus Xanthus, ” Biotechnology and Bioengineering78(3):280-288.
Nicolaou, K.C. et al. (1998). “Chemical biology of epothilones,”Angew Chem Int Ed37(15):2014-2045.
Pfeifer, B. A. et al. (2001). “Biosynthesis of polyketides in heterologous hosts,”Microbiology and Molecular Biology Reviews65(1):106/118.
Regentin, R. et al. (2001). “Development of a cost effective epothilone D process inmyxococcus xanthus, ” Abstracts of Papers American Chemical Society221(1-2):BIOT 61.
Shimkets, L.J. (1993). “Chapter 12: Industrial relevance and genetic analysis of myxobacteria,”Industrial Microorganisms: Basic and Applied Molecular Genetics 5thASM pp. 85-96.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cystobacterineae host cells containing heterologous PKS... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cystobacterineae host cells containing heterologous PKS..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cystobacterineae host cells containing heterologous PKS... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3616184

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.