Cystic fibrosis treatment methods

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

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Details

C514S169000, C514S172000, C514S176000, C514S177000, C514S178000, C540S106000, C552S516000, C552S519000, C552S522000

Reexamination Certificate

active

07910571

ABSTRACT:
The invention relates to the use of compounds to ameliorate or treat an condition such as a cystic fibrosis, neutropenia or other exemplified conditions. Exemplary compounds that can be used include 3β-hydroxy-17β-aminoandrost-5-ene, 3β-hydroxy-16α-fluoro-17β-aminoandrost-5-ene, 3α-hydroxy-16α-fluoro-17β-aminoandrost-5-ene, 3β-hydroxy-16β-fluoro-17β-aminoandrost-5-ene, 1α,3β-dihydroxy-4α-fluoroandrost-5-ene-17-one, 1α,3β,17β-trihydroxy-4α-fluoroandrost-5-ene, 1β,3β-dihydroxy-6α-bromoandrost-5-ene, 1α-fluoro-3β,12α-dihydroxyandrost-5-ene-17-one, 1α-fluoro-3β,4α-dihydroxyandrost-5-ene and 4α-fluoro-3β,6α,17β-trihydroxyandrostane.

REFERENCES:
patent: 2566336 (1951-09-01), Julian et al.
patent: 3001988 (1961-09-01), Nysted
patent: 3137710 (1964-06-01), de Ruggieri et al.
patent: 3153063 (1964-10-01), de Ruggieri et al.
patent: 3155690 (1964-11-01), Cole
patent: 3169093 (1965-02-01), Davis
patent: 3189597 (1965-06-01), MacPhillamy et al.
patent: 4330539 (1982-05-01), Sleigh et al.
patent: 4898694 (1990-02-01), Schwartz et al.
patent: 4908358 (1990-03-01), Schreiber
patent: 5206008 (1993-04-01), Loria
patent: 5387583 (1995-02-01), Loria
patent: 5461042 (1995-10-01), Loria
patent: 5506223 (1996-04-01), Lardy et al.
patent: 5585371 (1996-12-01), Lardy
patent: 5635496 (1997-06-01), Daynes et al.
patent: 5686438 (1997-11-01), Daynes et al.
patent: 5811418 (1998-09-01), Daynes et al.
patent: 7396827 (2008-07-01), Ahlem et al.
patent: 7462610 (2008-12-01), Lardy et al.
patent: 7482334 (2009-01-01), Frincke et al.
patent: 7524835 (2009-04-01), Frincke
patent: 7547687 (2009-06-01), Frincke et al.
patent: 2006/0073099 (2006-04-01), Frincke
patent: 2007/0077201 (2007-04-01), Reading et al.
patent: 2007/0129282 (2007-06-01), Ahlem
patent: 2007/0213309 (2007-09-01), Reading et al.
patent: 2007/0265236 (2007-11-01), Reading et al.
patent: 2008/0058301 (2008-03-01), Lardy
patent: 2008/0085873 (2008-04-01), Reading et al.
patent: 2008/0176823 (2008-07-01), Lardy
Arth, G., et al, Steroidal androgen biosynthesis inhibitors,J. Med. Chem., 14(8):675-679 (1971).
Davis, M., et al, Steroid Amines. Part II. 17α-aminoandrostane derivatives,J. Chem. Soc., 1698-1700 (1966).
Flouret, G., et al, 17-aminocylamido-5-androsten-3β-ols,J. Med. Chem., 11:880-882 (1968).
Hewett, C., et al, Amino-steroids. Part IV. 16β-morpholino-17-oxo- and 17β-morpholino-16-oxo-5α-androstanes,J. Chem. Soc., 1880-1883 (1969).
Hussain, A., et al, Testosterone 17β-N, N-dimenthylglycinate hydrochloride: A prodrug with a potential for nasal delivery of testosterone,J. Pharmaceutical Sciences, 91:785-789 (2002).
Irmscher, K., et al, Cholesterol analogues with oxa and oxa-aza side chain a novel class of inhibitors of cholesterol biosynthesis,Steroids, 7(6):557-576 (1966).
Johnson, K., et al, Solution kinetics of a water soluble hydrocortisone prodrug: Hydrocortisone-21-lysinate,J. Pharmaceutical Sciences, 74(1):87-89 (1985).
Jones, J., et al, Steroids and steroidases. 10. Studies on some potentially antitumor active androstane compounds containing C-17 nitrogen mustard functions,J. Med. Chem., 14:(9) 827-833 (1971).
Kabara, J., et al, Structure-function activity of azasterols and nitrogen-containing steroids,Lipids, 11(10):755-762 (1976).
Mokotoff, M., et al, Peptidyl aminosteroids as potential new antiarrhythmic agents,Steroids, 55:399-404 (1990).
Pettit, G., et al, Structural biochemistry. IV. 3β-hydroxy-17β-(L-prolyl) amino-androst-5-ene1-3,Canadian J. Chem., 45:502-507 (1967).
Pettit, R., et al, Antimicrobial and cancer cell growth inhibitory activities of 3β-acetoxy-17β-(L-prolyl)amino-5α-androstanein vitro, International J. Antimicrob. Agents, 15:299-304 (2000).
Robinson, C., et al, the synthesis of 17α-amino-5-androsten-3β-ol; N.M.R. spectra of 17-substituted androstanes,Steroids, 6(5):509-518 (1965).
Yagishita, K, Studies on antimicrobial activities of aminosteroids—II,Bull Coll Agr&Vet Med, Nihon Univ, 28:8-17 (1971).
Zheng, G, et al, Tricarbocyanine cholesteryl laureates labeled LDL: New near infrared fluorescent probes (NIRFs) for monitoring tumors and gene therapy of familial hypercholesterolemia,Bioorganic&Med. Chem. Letters, 12:1485-1488 (2002).
U.S. Appl. No. 11/549,598, filed Oct. 13, 2006, Reading et al.

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