Cystic fibrosis treatment

Details Cystic fibrosis treatment Cystic fibrosis treatment

1996-03-22

1998-11-24

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 24, 514 25, 514866, A61K 3170

Patent

active

058407022

ABSTRACT:
The present invention provides a method of stimulating expression of a functional full-length cystic fibrosis transmembrane conductance regulator protein in an individual in need of such treatment, comprising the step of administering to said individual a pharmacologically effective dose of an aminoglycoside. Also provided is a method of treating cystic fibrosis in an individual in need of such treatment, comprising the step of administering to said individual a therapeutically effective dose of an aminoglycoside. Further provided is a method of screening for a drug useful in the treatment of an individual having cystic fibrosis, comprising the step of determining said drug's ability to suppress premature stop mutations in a model of cystic fibrosis and a method of pharmacologically suppressing premature stop mutations in an individual having such mutations, comprising the step of administering to said individual a pharmacologically effective dose of an aminoglycoside.

REFERENCES:
patent: 5384128 (1995-01-01), Meezan et al.
patent: 5441938 (1995-08-01), Speert et al.
Chemical Abstracts (107:228540) 1997. Oliver et al.

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