Cystic fibrosis therapy

Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Blood

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424531, 424532, 514 2, 514 21, A61K 3516

Patent

active

058559183

ABSTRACT:
The invention provides methods for treating cystic fibrosis and other pathological conditions in mammals using hepatocyte growth factor ("HGF"). The invention also provides articles of manufacture and kits containing HGF.

REFERENCES:
patent: 5227158 (1993-07-01), Jardieu et al.
patent: 5316921 (1994-05-01), Godowski et al.
patent: 5328837 (1994-07-01), Godowski et al.
Remington's Pharmaceutical Sciences, Oslo et al., eds., 16th edition, Mack Publishing Co. (1980).
Asami et al., "Purification and Characterization of Hepatocyte Growth Factor from Injured Liver of Carbon Tetrachloride-Treated Rats" J. Biochem. 109:8-13 (1991).
Bottaro et al., "Identification of the Hepatocyte Growth Factor Receptor as the c-met Proto-Oncogene Product" Science 251:802-804 (Feb. 15, 1991).
Boucher et al., "Na.sup.+ Transport in Cystic Fibrosis Respiratory Epithelia" J. Clin. Invest. 78:1245-1252 (1986).
Chan et al., "Identification of a Competitive HGF Antagonist Encoded by an Alternative Transcript" Science 254:1382-1385 (1991).
Chan et al., "Isoforms of Human HGF and Their Biological Activities" Hepatocyte Growth Factor-Scatter Factor (HGF-SF) and the C-Met Receptor, I.D. Goldberg and E.M. Rosen eds., Basel:Birkhauser Verlag pp. 67-79 (1993).
Clarke et al., "Defective Epithelial Chloride Transport in a Gene-Targeted Mouse Model of Cystic Fibrosis" Science 257:1125-1128 (1992).
Comoglio, "Structure, Biosynthesis and Biochemical Properties of the HGF Receptor in Normal and Malignant Cells" Hepatocyte Growth Factor-Scatter Factor (HGF-SF) and the C-Met Receptor, I.D. Goldberg and E.M. Rosen eds., Basel:Birkhauser Verlag pp. 131-165 (1993).
Crepaldi et al., "Targeting of the SF/HGF Receptor to the Basolateral Domain of Polarized Epithelial Cells" The Journal of Cell Biology 125(2):313-320 (1994).
Di Renzo et al., "Selective Expression of the Met/HGF Receptor in Human Central Nervous System Microglia" Oncogene 8:219-222 (1993).
Fuller et al., "Cloning of a Bovine Renal Epithelial Na.sup.+ Channel Subunit" Am. J. Physiol. 269:C641-C654 (1995).
Furlong, "The Biology of Hepatocyte Growth Factor/Scatter Factor" BioEssays 14:613-617 (1992).
Giordano et al., "Transfer of Motogenic and Invasive Response to Scatter Factor/Hepatocyte Growth Factor by Transfection of Human met Protooncogene" Proc. Natl. Acad. Sci. USA 90:649-653 (Jan. 1993).
Gohda et al., "Purification and Partial Characterization of Hepatocyte Growth Factor from Plasma of a Patient with Fulminant Hepatic Failure" J. Clin. Invest. 81:414-419 (1988).
Han et al., "Characterization of the DNF15S2 Locus on Human Chromosome 3: Identification of a Gene Coding for Four Kringle Domains with Homology to Hepatocyte Growth Factor" Biochemistry 30:9768-9780 (1991).
Hartmann et al., "A Functional Domain in the Heavy Chain of Scatter Factor/Hepatocyte Growth Factor Binds the c-Met Receptor and Induces Cell Dissociation but Not Mitogenesis" Proc. Natl. Acad. Sci. USA 89:11574-11578 (Dec. 1992).
Igawa et al., "Hepatocyte Growth Factor is a Potent Mitogen for Cultured Rabbit Renal Tubular Epithelial Cells" Biochem. & Biophys. Res. Comm. 174(2):831-838 (Jan. 31, 1991).
Jetten et al., "Persistence of Abnormal Chloride Conductance Regulation in Transformed Cystic Fibrosis Epithelia" Science 244:1472-1475 (1989).
Jiang et al., "Altered Fluid Transport Across Airway Epithelium in Cystic Fibrosis" Science 262:424-427 (1993).
Knowles et al., "Activation by Extracellular Nucleotides of Chloride Secretion in the Airway Epithelia of Patients with Cystic Fibrosis" New England J. of Medicine 325:533-538 (1991).
Lindroos et al., "Hepatocyte Growth Factor (Hepatopoietin A) Rapidly Increases in Plasma before DNA Synthesis and Liver Regeneration Stimulated by Partial Hepatectomy and Carbon Tetrachloride Administration" Hepatology 13(4):743-750 (1991).
Lokker and Godowski, "Generation and Characterization of a Competitive Antagonist of Human Hepatocyte Growth Factor, HGF/NK1" Journal of Biological Chemistry 268:17145-17150 (1993).
Lokker et al., "Structure-Function Analysis of Hepatocyte Growth Factor: Identification of Variants that Lack Mitogenic Activity Yet Retain High Affinity Receptor Binding" EMBO Journal 11(7):2503-2510 (1992).
Matsumoto et al., "Deletion of Kringle Domains or the N-Terminal Hairpin Structure in Hepatocyte Growth Factor Results in Marked Decreases in Related Biological Activities" Biochem. & Biophys. Res. Comm. 181(2):691-699 (Dec. 16, 1991).
Matsumoto et al., "Hepatocyte Growth Factor is a Potent Stimulator of Human Melanocyte DNA Synthesis and Growth" Biochem. & Biophys. Res. Comm. 176(1):45-51 (Apr. 15, 1991).
McDonald et al., "Liddle's Syndrome Mutations Increase Activity of the Epithelial Na.sup.+ Channel" American Society Cell Biology (1995).
Michalopoulos et al., "Control of Hepatocyte Replication by Two Serum Factors" Cancer Research 44:4414-4419 (Oct. 1984).
Miyazawa et al., "An Alternatively Processed mRNA Generated from Human Hepatocyte Growt Factor Gene" European Journal of Biochemistry 197:15-22 (1991).
Miyazawa et al., "Molecular Cloning and Sequence Analysis of cDNA for Human Hepatocyte Growth Factor" Biochem. & Biophys. Res. Comm. 163(2):967-973 (Sep. 15, 1989).
Montesano et al., "Identification of a Fibroblast-Derived Epithelial Morphogen as Hepatocyte Growth Factor" Cell 67:901-908 (Nov. 29, 1991).
Naka et al., "Activation of Hepatocyte Growth Factor by Proteolytic Conversion of a Single Chain Form to a Heterodimer" The Journal of Biological Chemistry 267(28):20114-20119 (1992).
Nakamura et al., "Molecular Cloning and Expression of Human Hepatocyte Growth Factor" Nature 342:440-443 (Nov. 23, 1989).
Nakamura et al., "Partial Purification and Characterization of Hepatocyte Growth Factor from Serum of Hepatectomized Rats" Biochem. & Biophys. Res. Comm. 122:1450-1459 (Aug. 16, 1984).
Nakamura et al., "Purification and Characterization of a Growth Factor from Rat Platelets for Mature Parenchymal Hepatocytes in Primary Cultures" Proc. Natl. Acad. Sci. USA 83:6489-6493 (1986).
Nakamura et al., "Purification and Subunit Structure of Hepatocyte Growth Factor from Rat Platelets" FEBS Letters 224(2):311-316 (Nov. 1987).
Naldini et al., "Hepatocyte Growth Factor (HGF) Stimulates the Tyrosine Kinase Activity of the Receptor Encoded by the Proto-Oncogene c-MET" Oncogene 6:501-504 (1991).
Naldini et al., "Scatter Factor and Hepatocyte Growth Factor are Indistinguishable Ligands for the MET Receptor" EMBO Journal 10(10):2867-2878 (1991).
Okajima et al., "Primary Structure of Rat Hepatocyte Growth Factor and Induction of Its mRNA During Liver Regeneration Following Hepatic Injury" European Journal of Biochemistry 193:375-381 (1990).
Panos et al., "Keratinocyte Growth Factor and Hepatocyte Growth Factor/Scatter Factor are Heparin-binding Growth Factors for Alveolar Type II Cells in Fibroblast-conditioned Medium" J. Clin. Investigation 92:969-977 (1993).
Park et al., "Sequence of MET Protooncogene cDNA has Features Characteristic of the Tyrosine Kinase Family of Growth-Factor Receptors" Proc. Natl. Acad. Sci. USA 84:6379-6383 (1987).
Ponzetto et al., "c-met is Amplified But Not Mutated in a Cell Line with an Activated met Tyrosine Kinase" Oncogene 6:553-559 (1991).
Prat et al., "C-Terminal Truncated Forms of Met, the Hepatocyte Growth Factor Receptor" Molecular & Cellular Biology 11(12):5954-5962 (1991).
Rodrigues et al., "Alternative Splicing Generates Isoforms of the met Receptor Tyrosine Kinase Which Undergo Differential Processing" Molecular & Cellular Biology 11(6):2962-2970 (1991).
Roos et al., "Induction of Liver Growth in Normal Mice by Infusion of Hepatocyte Growth Factor/Scatter Factor" Am. J. Physiol. 268:G380-G386 (1995).
Rubin et al., "A Broad-Spectrum Human Lung Fibroblast-Derived Mitogen is a Variant of Hepatocyte Growth Factor" Proc. Natl. Acad. Sci. USA 88:415-419 (1991).
Russell et al., "Partial Characterization of a Hepatocyte Growth Factor From Rat Platelets" J. Cellular Physiology 119:183-192 (1984).
Seki et al., "Isolation and Expression of cDNA for Different Forms of Hepatocyte Growth Factor from Human Leukocyte" Biochem. and Biop

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cystic fibrosis therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cystic fibrosis therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cystic fibrosis therapy will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-859894

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.