Cystic fibrosis gene

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C536S023100, C530S350000

Reexamination Certificate

active

06984487

ABSTRACT:
The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.

REFERENCES:
patent: 4322274 (1982-03-01), Wilson et al.
patent: 4844893 (1989-07-01), Honsik et al.
patent: 4847201 (1989-07-01), Kaswasaki et al.
patent: 4853331 (1989-08-01), Herrnstadt et al.
patent: 4861589 (1989-08-01), Ju
patent: 4861719 (1989-08-01), Miller
patent: 4868116 (1989-09-01), Morgan et al.
patent: 4980286 (1990-12-01), Morgan et al.
patent: 5240846 (1993-08-01), Collins et al.
patent: 5407796 (1995-04-01), Cutting et al.
patent: 0 226 288 (1986-08-01), None
patent: 0 288 299 (1988-10-01), None
patent: 0 446 017 (1991-09-01), None
patent: 0 446 017 (1991-09-01), None
patent: 2203742 (1987-04-01), None
patent: WO 94/12649 (1994-09-01), None
Kolata, Gina “Cystic Fibrosis Surprise: Genetic Screening Falters.” The New York Times, Issued Nov. 16, 1993.
Watkins et al Am. J. Hu. Gen. 36(4)Supp (1984).
Rommens et al. Science 245:1060 (1989).
Riordan et al. Science 245:1066 (1989).
Smith. et al. Clin. Chem. 35(1317-1320) (1989).
Fulton et al. Nucl. Acid Res 17(1):271 (1989).
Watkins et al. Am.J. Hum Gen. 36(4 Supp.) (1989).
Bear et al., Purification and Functional Reconstitution of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR),Cell 68:809-818 (1992).
Boat et al., Human Respiratory Tract Secretions,Arch. Biochem. Biophys. 177:95-104 (1976).
Boucher et al., Na+Transport in Cystic Fibrosis Respiratory Epithelia,J. Clin. Invest. 78:1245-1252 (1986).
Buchwald et al., Current Status of the Genetics of Cystic Fibrosis, in Cystic Fibrosis, pp. 19-29, Alan R. Liss, Inc. (1987).
Cheng et al., Increased Sulfation of Glycoconjugates by Cultured Nasal Epithelial Cells from Patients with Cystic Fibrosis,J. Clin. Invest. 84:68-72 (1989).
Cliff et al., Separate C1−Conductances Activated by cAMP and Ca2+in C1-−Secreting Epithelial Cells,Proc. Natl. Acad. Sci. USA 87:4956-4960 (1990).
Cutting et al., A Cluster of Cystic Fibrosis Mutations in the First Nucleotide-Binding Fold of the Cystic Fibrosis Conductance Regulator Protein,Nature 346:366-369 (1990).
The Cystic Fibrosis Genetic Analysis Consortium,Am. J. Hum. Genet. 47:354-359 (1990).
Dean et al., Multiple Mutations in Highly Conserved Residues are Found in Mildly Affected Cystic Fibrosis Patients,Cell 61:863-870 (1990).
Drumm et al., Correction of the Cystic Fibrosis Defect In Vitro by Retrovirus—Mediated Gene Transfer,Cell 62:1227-1233 (1990).
Farrall et al., Recombinations between IRP and Cystic Fibrosis,Am. J. Hum. Genet. 43:471-475 (1988).
Fienberg et al., A Technique for Radiolabeling DNA Restriction Endonuclease Fragments to High Specific Activity,Anal. Biochem. 132:6-13 (1983).
Frizzell, R.A., Cystic Fibrosis: A Disease of Ion Channels,Trends Neurosci. 10:190-193 (1987).
Green et al., Chromosomal Region of the Cystic Fibrosis Gene in the Yeast Artificial Chromosomes: A Model for Human Genome Mapping,Science 250:94-98 (1990).
Hyde et al., Structural Model of ATP-Binding Proteins Associated with Cystic Fibrosis, Multidrug Resistance and Bacterial Transport,Nature 346:362-365 (1990).
Jensen et al., Chloride Channel Expression in Cultures of Sweat Gland Epithelia in Cystic Fibrosis,J. Cell Biol. 107(6):139a, Abstract No. 788 (1989).
Kartner et al., Expression of the Cystic Fibrosis Gene in Non-Epithelial Invertebrate Cells Produces a Regulated Anion Conductance,Cell 64:681-691 (1991).
Kerem et al., Identification of the Cystic Fibrosis Gene: Genetic Analysis,Science 245:1073-1080 (Sep. 8, 1989).
Kerem et al., Identification of Mutations in Regions Corresponding to the Two Putative Nucleotide (ATP)-Binding Folds of the Cystic Fibrosis Gene,Proc. Natl. Acad. Sci. USA 87:8447-8451 (1990).
Korman et al., Expression of Human Class II Major Histocompatibility Complex Antigens Using Retrovirus Vectors,Proc. Natl. Acad. Sci. USA 84:2150-2154 (1987).
Koshland, D.E., The Cystic Fibrosis Gene Story,Science 245:1029 (Sep. 8, 1989).
Landry et al., Purification and Reconstitution of Chloride Channels from Kidney and Trachea,Science 244:1469-1472 (1989).
Li et al., Cyclic AMP-Dependent Protein Kinase Opens Chloride Channels in Normal but not Cystic Fibrosis Airway Epithelium,Nature 331:358-360 (1988).
Marx, J.L., The Cystic Fibrosis Gene is Found,Science 245:923-925 (Sep. 1, 1989).
Meakin et al., γ-Crystallins of the Human Eye Lens: Expression Analysis of Five Members of the Gene Family,Mol. Cell. Biol. 7(8):2671-2679 (1987).
Quinton, P.M., Cystic Fibrosis: A Disease in Electrolyte Transport,FASEB J. 4:2709-2717 (1990).
Rommens et al., Genetic and Physical Mapping of the Chromosomal Region Containing the Cystic Fibrosis Locus,Am. J. Hum. Genetics 43(3Suppl.):A199 (Abstract No. 0794) (1988).
Rommens et al., cAMP-Inducible Chloride Conductance in Mouse Fibroblast Lines Stably Expressing the Human Cystic Fibrosis Transmembrane Conductance Regulator,Proc. Natl. Acad. Sci. USA 88:7500-7504 (1991).
Sanbrook et al., Oligonucleotide-Mediated Mutagenesis, inMolecular Cloning, A Laboratory Manual, 2nd Ed., Cold Spring Harbor Press, Cold Spring Harbor, NY, 15.51-15.80 (1989).
Sato et al., Defective Beta Adrenergic Response of Cystic Fibrosis Sweat Glands in Vivo and in Vitro,J. Clin. Invest. 73:1763-1771 (1984).
Schoumacher et al., Phosphorylation Fails to Activate Chloride Channels from Cystic Fibrosis Airway Cells,Nature 330:752-754 (1987).
Schoumacher et al., A Cystic Fibrosis Pancreatic Adencarcinoma Cell Line,Proc. Natl. Acad. Sci. USA 87:4012-4016 (1990).
Short et al., λ ZAP: A Bacteriophage λ Expression Vector with In Vivo Excision Properties,Nucleic Acids Research 16(15) :7583-7600 (1988).
Slot et al., No Evidence for Expression of the Insulin-Regulatable Glucose Transporter in Endothelial Cells,Nature 346:369-371 (1990).
Smith, M., In Vitro Mutagenesis,Ann. Rev. Genet. 19:423-462 (1985).
Taussig, L.M., Cystic Fibrosis: An Overview,In Cystic Fibrosis(L.M. Taussig, ed.) New York: Thieme-Stralton, pp. 1-9 (1984).
Venglarik et al., A Simple Assay for Agonist-Regulated Cl and K Conductances in Salt-Secreting Epithelial Cells,Am. J. Physiol. 259:C358-C364 (1990).
Wahl et al., Cosmid Vectors for Rapid Genomic Walking, Restriction Mapping and Gene Transfer,Proc. Natl. Acad. Sci. USA 84:2160-2164 (1987).
Wainwright et al., Localization of Cystic Fibrosis Locus to Human Chromosome 7cen-q22,Nature 318:384-385 (1985).
Welsh, M.J., Abnormal Regulation of Ion Channels in Cystic Fibrosis Epithelia,FASEB J. 4:2718-2725 (1990).
White et al., A Frame-Shift Mutation in the Cystic Fibrosis Gene,Nature 344:665-667 (1990).
Willumsen et al., Activation of an Apical Cl−Conductance by Ca2+Ionophores in Cystic Fibrosis Airway Epithelia,Am. J. Physiol. 256:C226-C233 (1989).
Wilson et al., Correction of the Genetic Defect in Hepatocytes from the Watanabe Heritable Hyperlipidemic Rabbit,Proc. Natl. Acad. Sci. USA 85:4421-4425 (1988).
Wilson et al., Correction of CD18-Deficient Lymphocytes by Retrovirus-Mediated Gene Transfer,Science 248:1413-1416 (1990).
Wilson et al., Expression of Human Adenosine Deaminase in Mice Reconstituted with Retrovirus-Transduced Hematopoietic Stem Cells,Proc. Natl. Acad. Sci. USA 87:439-443 (1990).
Zielenski et al., Genomic DNA Sequence of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene,Genomics 10:214-228 (1991).
Boat et al., in:The Metabolic Basis of Inherited Disease(Scriver et al., Eds.) McGraw-Hill Information Services Company, NY, pp. 2649-2680 (1989).
Tsui et al.,Science 230:1054-1057 (1985).
Zengerling et al.,Am. J. Hum. Genet. 40:228-236 (1987).
Rommens et al.,Am. J. Hum. Genet. 43:645-663 (1988).
White et al.,Nature 318:382-384 (1985).
Wainwright et al.,Nature 318:384-385 (1985).
Estivill et al.,Nature 326:840-845 (1987).
Collins et al.,Science 235:1046-1049 (1987).
Iannuzzi et al.,Am. J. Hum. Genet

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cystic fibrosis gene does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cystic fibrosis gene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cystic fibrosis gene will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3552062

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.