Cysteinized ribonuclease and targeting moiety conjugated...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

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C435S196000, C435S069100, C435S320100, C435S252300, C435S325000, C435S019000, C530S350000, C536S023200

Reexamination Certificate

active

07442536

ABSTRACT:
A cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1 is disclosed. A targeting moiety can be conjugated to the cysteine residue.

REFERENCES:
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patent: 2003/0099629 (2003-05-01), Goldenberg et al.
patent: 00/40608 (2000-07-01), None
patent: 01/18214 (2001-03-01), None
patent: 2004/061120 (2004-07-01), None
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PCT International Preliminary Report on Patentability, PCT/US04/14844 (May 12, 2004), completed Feb. 15, 2007.

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