Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1993-10-21
1995-08-08
Sidberry, Hazel F.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 792, 435974, 436518, 436531, 530317, 530324, 530334, 530336, 530345, 530402, 530403, 530404, C12Q 100
Patent
active
054397928
ABSTRACT:
Peptides immunoreactive with antibodies to native proteins, and which have at least two cysteine residues that contribute to mimicking an epitope of the protein, are prepared with the cysteine thiol groups protected. When deprotected, the peptides have enhanced immunoreactivity. The peptides are particularly useful for detecting antibodies or antigens associated with retroviruses, including the clinically important lymphotropic retroviruses HIV-1, HIV-2, HTLV-I, and HTLV-II.
REFERENCES:
patent: 4111924 (1978-09-01), Fujino et al.
patent: 4499080 (1985-02-01), Duflot et al.
patent: 4629783 (1986-12-01), Cosand
patent: 4689398 (1987-08-01), Wu et al.
Veber et al., J. Am. Chem. Soc. 94:5456-5461 (1972).
Young et al., Chem. Abstracts 95:169719 (1981).
Bernatowicz et al., Proc. 9th Am. Peptide Symposium (1987).
Brady et al., Proc. of 10th Am. Peptide Symposium (1988).
Storey et al, "Studies on Polypeptides. LI. Application S-Ethylcarbamoylcysteine to the Synthesis of a Protected Heptatetracontapeptide Related to the Primary Sequence of Ribonuclease T1", J. Am. Chem. Soc., 94 (17): 6170-6178 (1972).
Kiso et al, "A New Thiol Protecting Trimethylacetamidomethyl Group. Synthesis of a New Porcine Brain Natriuretic Peptide using the S-Trimethylacetamidomethyl-Cysteine", Tetrahedron Lett., 30 (15): 1979-1982 (1989).
Albericio et al, "Use of the Npys thiol protection in solid phase peptide synthesis. Application to direct peptide-protein conjugation through cysteine residues", Chem. Ab., 112(5):34141t (1990). Abstract of Int. J. Pept. Protein Res. 34(2): 124-8 (1989).
Blake James
Cole Carol-Ann
Coleman Patrick F.
Monji Nobuo
Montana John P.
Genetic Systems Corporation
Sidberry Hazel F.
Stucker Jeffrey
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